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| HIF-1α调控糖酵解在RA炎症发病机制中的研究 |
| Advances in the study of HIF-1 α regulation of glycolysis in the pathogenesis of RA inflammation |
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| DOI：10.3969/j.issn.1006-7108.2023.02.014 |
| 中文关键词: HIF-1α 糖酵解 类风湿关节炎 炎症 |
| 英文关键词:hypoxia inducible factor-1 α glycolysis rheumatoid arthritis inflammation |
| 基金项目:国家自然科学基金（82060891）；甘肃省自然科学基金项目（2JR7RA568）；甘肃省青年科技基金(20JR10RA344)；甘肃省皇甫谧针灸医院科研孵化项目(02) |
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| 中文摘要: |
| 类风湿关节炎(rheumatoid arthritis, RA)是一种常见的自身免疫性疾病，炎症是该病的主要表现。此外，缺氧诱导因子、糖酵解与RA的发病息息相关。本文主要综述了HIF-1α与糖酵解在RA发病中的作用，阐释了HIF-1α能够通过调控糖酵解在炎症、血管翳形成、软骨破坏等方面发挥作用，减轻RA症状。以期为RA的临床与基础研究提供新的思路，提高该病的临床疗效。 |
| 英文摘要: |
| Rheumatoid arthritis(RA) is a common autoimmune disease in which inflammation is the main manifestation of the disease. In addition, hypoxia-inducible factor and glycolysis are closely related to the pathogenesis of RA. In this paper, we reviewed the role of HIF-1α and glycolysis in the pathogenesis of RA, and explained that HIF-1α can play a role in inflammation, pus formation, cartilage destruction and
other aspects through regulating glycolysis, and play a role in alleviating RA symptoms. In order to
provide new ideas for the clinical and basic research of RA and improve the clinical efficacy of the
disease. |
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