| Osteoporosis (OP), as a common bone metabolic disease in clinical orthopedics, is mainly caused by the loss of dynamic balance between bone formation and bone resorption mediated by osteoblasts and osteoclasts, resulting in bone mass reduction, bone density decrease and bone microstructure change in unit volume of the body. Thus leading to the occurrence and development of OP. In the body of bone metabolic process is regulated by the multiple signaling pathways, neurogenic loci gap homologous protein (Notch) signal pathway as important bone reconstruction in regulation and maintain stability play a crucial role in bone metabolism, by affecting the pathway of protein expression, can be directly or indirectly control related bone cell proliferation, differentiation and apoptosis, Thus maintaining the dynamic relationship of "bone balance". In recent years, the application of traditional Chinese medicine in the prevention and treatment of OP has achieved good clinical efficacy. Scholars at home and abroad have conducted multi-level and multi-dimensional exploration on the mechanism of Notch signaling pathway in the prevention and treatment of OP by traditional Chinese medicine and found that there is an obvious correlation between traditional Chinese medicine, Notch signaling pathway and OP. In this paper, the literatures related to the regulation of Notch signaling pathway by monomers and compounds of traditional Chinese medicine in the prevention and treatment of OP were collected, sorted out, analyzed and summarized the current research status, hoping to provide a reference for the prevention and treatment of OP by traditional Chinese medicine, and provide new ideas for the development of new drugs and the application of traditional Chinese medicine characteristic diagnosis and treatment methods. |