| In order to promote the improvement of the curative effect of traditional Chinese medicine for postmenopausal osteoporosis and further study of its mechanism, the literatures of commonly used traditional Chinese medicine compounds for PMOP treatment from 2012 to 2021 are searched in the CNKI database. This paper summarized the syndrome differentiation of PMOP, the commonly used treatment formulas and mechanisms, and found that Chinese medicine treatment of PMOP can effectively relieve pain, improve bone mineral density, improve estradiol level and improve the quality of life of patients. In terms of mechanism, it can promote osteoblast differentiation, inhibit osteoclast formation, improve bone mineral density and balance bone metabolism by regulating OPG/RANKL signaling pathway, Wnt/β-catenin signaling pathway and JAK/STAT pathway, or by increasing OX, ERmRNA and protein expression. The research on the mechanism of TCM treatment of PMOP has reached the molecular and even genetic level. It is suggested that in the future, the bone metabolism, bone immunity, bone microstructure, intestinal flora, oxidative stress and inflammatory response, iron overload and other aspects can be further studied to enrich the mechanism of TCM treatment of PMOP, clarify the action targets of TCM, and enhance the scientific nature. |