| The spleen is centered to irrigate all sides, to govern the transportation, and to integrate the mussels. The spleen qi benefits transportation, leading to the source of qi and blood. The reasonable regulation by the spleen results in normal transformation from the diet to subtle substances, and transfusion through the heart and lung to nourish the tissues and organs of the whole body for the maintenance of the normal metabolism. When the spleen qi is weakened, the spleen loses the function of transportation, the digestive function of the diet is reduced, and the subtle absorption of the water valley is insufficient, then the body's metabolism is abnormal. Mitochondria involve in the synthesis of ATP to provide energy to cells. The pathway responsible for oxidation, the tricarboxylic acid cycle, and oxidative phosphorylation and other functions are similar to the spleen function of qi and blood biochemical sources. The disorder of iron metabolism in the mitochondrion is associated with many chronic diseases, such as osteoporosis, chronic anemia, and myasthenia gravis. Mitochondria are the metabolic sites for iron metabolism within cells. Iron is a versatile cofactor that is essential for many metabolic pathways. Mitochondrial iron homeostasis is basis for the metabolic regulation of maintenance of bone health. The stable regulation of mitochondrial iron metabolism promotes the normal differentiation of osteoclasts, which plays an important role in bone growth, repair and reconstruction. Iron overload increases bone absorption and oxidative stress, so that bone structure and components change, affecting bone health, resulting in osteoporosis. Therefore, based on the correlation between spleen and mitochondrial iron metabolism, this study explores the influence and mechanism of mitochondrial iron metabolism on bone health from the perspective of spleen governing transportation and transformation theory. |