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| 铁死亡与骨质疏松 |
| Ferroptosis and osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2023.03.023 |
| 中文关键词: 铁死亡 骨质疏松 骨代谢 |
| 英文关键词:ferroptosis osteoporosis bone metabolism |
| 基金项目:国家重点研发计划(2020YFC2004900)；北京医院管理局的攀登计划(DFL20190802)；北京市教育委员会科技计划项目(KZ202210025038) |
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| 中文摘要: |
| 骨质疏松是一种代谢性疾病，以骨量减少和骨骼微结构的破坏为特点，常导致骨折的发生。铁死亡作为2012年新发现的细胞程序性死亡，其主要的特征是铁过载和ROS的积累，从而导致脂质过氧化的发生。近来，越来越多的研究表明铁死亡在骨质疏松中扮演着重要作用，因此，本文就铁死亡在骨质疏松中的最新研究进展进行综述。 |
| 英文摘要: |
| Osteoporosis is a metabolic disease characterized by a decrease in bone density and destruction of bone microarchitecture, often resulting in fractures. As a newly discovered form of programmed cell death at 2012, ferroptosis is mainly characterized by iron overload and accumulation of ROS, leading to lipid peroxidation. Recently, more and more studies have shown that ferroptosis plays an important role in osteoporosis. Therefore, in this paper, the new research progress of ferroptosis and osteoporosis are reviewed. |
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