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| 代谢组学和蛋白组学在骨质疏松研究中的应用 |
| Application of metabonomics and proteomics in the study of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2023.03.027 |
| 中文关键词: 骨质疏松症 代谢组学 蛋白组学 |
| 英文关键词:osteoporosis metabonomics proteomics |
| 基金项目:国家自然科学基金-持续静压力下MC3T3-E1细胞应力转导信号与细胞骨架的响应机制及固本增骨颗粒的干预效应（81960877）；甘肃省高等学校创新基金-低机械应力通过TRIM21/F-actin信号影响MC3T3-E1细胞活性的机制研究及固本增骨丸含药血清的干预效应（2021A-076）；甘肃省科技计划（创新基地和人才计划）项目-高海拔环境对骨质疏松大鼠成骨作用影响机制及固本增骨颗粒的干预效应（21JR7RA561）；甘肃中医药大学学生科技学术创新基金项目-基于代谢组学和蛋白组学对骨质疏松的对比分析及研究进展（xskj-202021） |
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| 中文摘要: |
| 骨质疏松症（osteoporosis，OP）是以全身骨密度降低和骨组织微结构退化为特征的慢性骨骼疾病。骨质疏松症已成为一个严重的社会问题而备受广泛关注。近年来，国内外学者通过蛋白组学及代谢组学探究骨质疏松症的发病机制、诊断及防治，虽已取得初步进展，但研究不够系统、完善。笔者查阅相关文献，将对代谢组学和蛋白组学在骨质疏松症中的应用进行对比分析，并对骨质疏松症研究进展进行综述，以期为骨质疏松症的发病机制、诊断及防治提供理论参考。 |
| 英文摘要: |
| Osteoporosis is a chronic bone disease characterized by the decrease of bone mineral density and the degeneration of bone microstructure. Osteoporosis has become a serious social problem and attracted much attention from scholars. In recent years, scholars at home and abroad have explored the pathogenesis, diagnosis, and prevention of osteoporosis through proteomics and metabonomics. Although preliminary progress has been made, the research is not systematic and perfect. The authors compare and analyze the application of metabonomics and proteomics in osteoporosis, and summarize the research progress to provide theoretical reference for the pathogenesis, diagnosis, and prevention of osteoporosis. |
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