| Objective To investigate the correlation between Singh index and serum bone metabolism biochemical indexes in middle-aged and elderly patients with hipfragility fracture. Methods The data of 71 middle-aged and elderly patients with hip fragility fractures (including femoral neck fractures and femoral intertrochanteric fractures) admitted to the Department of Joint Surgery, the Affiliated Hospital of Jiangsu University from January 2019 to July 2022 were retrospectively analyzed, including demographic data, serum biochemical indicators, and related biochemical indicators of bone metabolism,which included Parathyroid hormone (PTH), 25-hydroxyvitamin D3 (25(OH) D3), insulin-like growth factor-1 (IGF-1), and Singh index of the contralateral proximal femur were evaluated by X-ray film. The patients were divided into three groups according to the Singh index measured by the upper femur anteroposition X-ray film. The differences in general data, ALB, ALP, PTH, 25(OH)D3, and IGF-1 among the three groups were analyzed by Mann-Whitney U test and Sperman correlation test. Ordinal logistic regression analysis was used to analyze the risk factors related to the trabecular bone quality of proximal femur. Results ①The results of Single factor analysis showed that there were significant differences in 25(OH)D3 and IGF-1 among the three groups (P < 0.05). The level of 25(OH)D3 in severe Singh index group (16.5(12.52-20.14)) was significantly lower than that in mild Singh index group (24.63(21.55-29.22)), and the difference was statistically significant (P=0.006). IGF-1 level in severe Singh index group (64.65(48.975-87.725)) was significantly lower than that in moderate Singh index group (90.2(69.55-133.4)), and the difference was statistically significant (P=0.025). Correlation analysis showed that the severity of Singh index was negatively correlated with the levels of 25(OH)D3 and IGF-1 (P < 0.05). ②Ordered logistic regression indicated that IGF-1 and 25(OH)D3 might be risk factors affecting the classification of Singh index. Conclusion The trabecular type index of proximal femur in middle-aged and elderly patients with hip brittleness fractures is negatively correlated with serum 25(OH)D3 and IGF-1 levels, which may be an important factor affecting bone quality in middle-aged and elderly patients with hip brittleness fractures. |