| Objective To investigate the correlation between systemic inflammatory parameters and other inflammatory parameters and bone mineral density (BMD) in male patients with primary osteoporosis. Methods A total of 311 male patients meeting the inclusion and exclusion criteria were selected from the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2021 to May 2022. The patients were divided into osteoporosis group, osteopenia group, and normal bone mass group according to the diagnostic criteria and were retrospectively studied. Results SII, NLR, MLR, and ESR in osteoporosis group were significantly higher than those in normal bone mass group, and the difference was statistically significant (P<0.05). Binary logistics regression analysis showed that PLR (P<0.05) and ESR (P<0.05) were risk factors for primary osteoporosis in men. The receiver operating characteristic (ROC) curve showed that the area under the PLR curve was 0.658, with a cut-off value of 189.17. The area under the curve of ESR was 0.639, and the cut-off value was 18.50. The area under the combined curve of multiple indicators was 0.713. The results of correlation analysis between BMD of different parts in male patients with primary osteoporosis and inflammation index showed that SII, NLR, PLR, CRP, ESR, and L1-L4 were negatively correlated with BMD, with statistical significance (P<0.05). MLR and L1-L4 BMD had no obvious correlation. In addition, SII, NLR, MLR, PLR, CRP, and ESR were negatively correlated with BMD of the left femoral neck and the left hip joint, with statistical significance (P<0.05). Conclusion BMD in male patients with primary osteoporosis is correlated with inflammatory indicators such as SII, NLR, MLR, PLR, CRP, and ESR. |