| Osteoimmunology is a discipline that studies bone regeneration and bone repair by studying the interaction between the skeletal system and immune system to explore the balance of bone metabolism and bone immunity. From the viewpoint of bone immunity, it is believed that bone immune disorder exists in the development of orthopedic diseases, which is a state of persistent inflammation, and immune cells participate in the inflammatory process and play a key role. Both T helper 17 cells (Th17) and regulatory T cells (Treg) are subsets of CD4+T cells, and their balance plays an important role in maintaining the stability of bone metabolism and the development of inflammation. Th17 directly or indirectly promote the development of inflammation and promote the activation of osteoclasts and bone resorption, while Treg and the secreted cytokines inhibit the inflammatory response, inhibit the formation of osteoclasts, and reduce bone loss and have a bone protective effect. Studies have shown Th17/Treg disorders in osteoarthritis, rheumatoid arthritis, osteoporosis, and other bone-related diseases. In order to better understand the mechanism of Th17/Treg in bone-related diseases, this paper reviews the research progress of Th17/Treg in bone-related diseases, in order to provide reference for the research of related diseases. |