| Postmenopausal osteoporosis (PMOP) is a disease characterized by bone mass reduction and the destruction of bone microstructure, which is caused by the lack of estrogen. In recent years, more and more people believe that the immune microenvironment is closely related to the occurrence and development of this disease. A variety of immune cells and their secreted cytokines regulate the biological functions of osteoblasts and osteoclasts through RANK/RANKL/OPG signaling pathways, thereby affecting the imbalance of bone homeostasis. Therefore, immune microenvironment based on bone immunology have gradually become one of the main targets in the prevention and treatment of PMOP. This article reviews the effects of immune cells related to bone metabolism such as T cells, B cells, macrophages, mast cells and monocytes on the occurrence and development of PMOP and fracture healing, and summarizes the therapeutic targets of PMOP based on bone immunology, in order to provide new ideas for the drug development and clinical application of PMOP in the future. |