| Osteoporosis is a systemic bone disease characterized by low bone mass, damage to bone tissue microstructure, increased bone fragility, and susceptibility to fractures. Osteoporosis is a multifactorial and polygenic disease, which is the result of the interaction between genetic and environmental factors. This article discusses the biological characteristics of Calcitonin receptor gene, parathyroid hormone receptor gene, estrogen receptor gene, tumor necrosis factor gene, insulin-like growth factor 1 receptor gene, osteoprotegerin gene, transforming growth factor gene, vitamin D receptor gene, type I collagen gene and their association with bone density, osteoporosis, and osteoporotic fractures, which are the pathogenesis, prevention and treatment of osteoporosis The development and research of new drugs provide molecular biology basis. |