| Sarco-osteoporosis is a geriatric syndrome in which sarcopenia coexists with osteoporosis. Sarco-osteoporosis has become a significant health threat to the elderly due to the increasing aging process of the society. There is currently strong evidence pointing to the beneficial effects of specific dietary interventions to prevent sarco-osteoporosis. Protein, amino acids, and creatine being the most studied nutrients in this regard. However, creatine has been much less studied than others. Therefore, this review aims to summarize the results of recent studies on the use of creatine supplementation as adjuvent therapy in the prevention of sarco-osteoporosis. The preliminary elaboration of the role of creatine in bone, muscle, and fat may provide new research ideas not only for the study of the possible mechanism of creatine on bone, muscle, and fat, but also for the prevention and treatment sarco-osteoporosis. Although there are conflicting views in the effects of creatine administration on bone, muscle, and fat, there is ample evidence that supplementation with appropriate amounts of creatine may help to reduce sarco-osteoporosis. |