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| microRNA-21调节Wnt/β-catenin信号通路防治骨质疏松症的研究进展 |
| Research progress in the regulation of Wnt/β-catenin signaling pathway by microRNA-21 in the prevention and treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2023.07.015 |
| 中文关键词: microRNA-21 Wnt/β-catenin 信号通路 骨质疏松 |
| 英文关键词:microRNA-21 Wnt/β-catenin signaling pathway osteoporosis |
| 基金项目:国家自然科学基金（82160911）；甘肃省拔尖领军人才项目（省委人才小组函[2021]2号）；甘肃省科技计划资助项目（20JR5RA129）；甘肃省中医药研究中心开放课题（zyzx-2020-32）；中医药传承创新建设平台（甘卫中医函2020203）；兰州市人才创新创业项目（2021-RC-131） |
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| 中文摘要: |
| 骨质疏松症作为老年骨科中的一种代谢性及慢性疾病，主要表现为骨密度降低及骨骼脆性增加。microRNA-21作为最为密切的骨质疏松症相关微小因子，能够发挥调节作用进而抑制骨质疏松症的进展。Wnt/β-catenin信号通路作为与骨质疏松症相关的经典信号通路，对延缓骨质疏松症的进展具有重要的作用。microRNA-21通过调节该信号通路的表达，进而防治骨质疏松症的进展。该文就microRNA-21与该信号通路的相关性及在防治骨质疏松症方面的作用进行综述，以期从微小分子方面探讨新的防治骨质疏松症的途径，为骨质疏松症的研究提供更多的理论依据。 |
| 英文摘要: |
| Osteoporosis is a metabolic and chronic disease in elderly orthopedics, characterized by decreased bone mineral density and increased bone fragility. As the most closely related micro-factor of osteoporosis, microRNA-21 plays a regulatory role and inhibits the progress of osteoporosis. As a classical signaling pathway related to osteoporosis, Wnt/β-catenin signaling pathway plays an important role in delaying the progression of osteoporosis. MicroRNA-21 prevents the progression of osteoporosis by regulating the expression of this signaling pathway. This article reviews the correlation between microRNA-21 and this signaling pathway and its role in the prevention and treatment of osteoporosis, in order to explore new ways to prevent and treat osteoporosis from the perspective of micro-molecules and to provide more theoretical basis for the study of osteoporosis. |
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