| osteoporosis is a chronic systemic metabolic bone disease, which results in the decrease of bone mass and bone mineral density due to the imbalance between bone resorption and bone formation. at the same time, the destruction of bone tissue microstructure leads to an increase in the risk of fracture, threatening the quality of life and safety of patients. At present, it is considered that the pathogenesis of osteoporosis is related to hormone, endocrine, immunity, intestinal flora and other factors. In recent years, The microbiota-gut-bone axis has become a research hotspot in the field of bone metabolism. This review will describe the pathogenesis of intestinal flora in osteoporosis from the aspects of intestinal mucosal barrier, bone immunology, metabolites of intestinal flora and so on. |