| Exosomes are extracellular vesicles released by most cells and are widely involved in intercellular material transport and information transfer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, have been identified as important components in exosomes, which can be selectively taken up by exosomes and delivered to recipient cells, thus regulating the physiological activities and functions of recipient cells. In recent years, studies have gradually focused on the close relationship between exosomal non-coding RNAs and osteoporosis. Based on this, this article reviews the exosomal non-coding RNAs in osteoporosis in the newly discovered, analyzes their roles in the regulation of osteogenic differentiation of bone marrow stem cells, bone matrix mineralization of osteoblasts, bone resorption of osteoclasts, viability and apoptosis of bone-related cells, and angiogenesis, hoping to identify their potential and challenges as new biomarkers and therapeutic targets in osteoporosis. |