| Objective To investigate the effect of bioavailable 25-(OH) Dand parathyroid hormone levels on functional recovery in elderly patients with brittle hip fractures after surgery. Methods A prospective cohort study of 318 adult patients with hip fractures from May 2017 to November 2021 in our hospital was enrolled. Levels of total 25-(OH)D, parathyroid hormone, calcium, albumin, and vitamin D-binding protein were measured. Self-designed questionnaires were collected. The bioavailable 25-(OH)D levels were calculated. A multivariate logistic regression model was used to analyze the association between bioavailable 25-(OH)D and parathyroid hormone levels and functional outcome in the elderly with fragile hip fractures. Receiver Operating Characteristic (ROC) was used to investigate the predictive value of bioavailable 25-(OH) D and parathyroid hormone levels, and postoperative function in the elderly with fragile hip fractures. Results A total of 318 patients were enrolled in this study. Total 25-(OH)D level (OR = 0.866,95% CI: 0.834-0.899, P < 0.001), bioavailable 25-(OH)D level (OR = 0.775,95% CI: 0.655-0.917, P = 0.003), and parathyroid hormone level (OR = 1.909,95% CI: 0.852-0.969, P = 0.004) were associated with rehabilitation outcomes. ROC curve analysis showed that the areas under the curve of total 25-(OH)D, bioavailable 25-(OH)D, and parathyroid hormone were 0.826, 0.644 and 0.579, respectively. Conclusion High total 25-(OH)D level, high bio-available 25-(OH) D level, and low parathyroid hormone level promote functional recovery after hip fracture surgery in the elderly. |