| Objective To evaluate the fracture risk of osteoporosis (OP) in patients with different syndrome types in traditional Chinese medicine (TCM) by using fracture risk assessment tool (FRAX?), and to explore the clinical characteristics of people at high risk of fracture from the view of TCM, with the aim of improving the precision of osteoporotic fracture risk assessment. Methods During the period from December 2021 to March 2022, a group of 125 women who had developed postmenopausal osteoporosis were selected to participate in the outpatient program offered by the Department of Orthopedics and Traumatology at Wuxi Affiliated Hospital of NJUCM. The patients were divided into four groups according to differentiating from traditional Chinese medicine, spleen and kidney yang deficiency group, liver and kidney yin deficiency group, kidney yang deficiency group, and stasis and blood stagnation group. The clinical data of the subjects were collected. FRAX? was used to calculate the likelihood of hip fractures (PHF) and the likelihood of large osteoporotic fractures (PMOF) in each group. The relationship between the syndrome types of postmenopausal osteoporosis in traditional Chinese medicine and the fracture risk was analyzed. Results BMI was significantly lower in the group with spleen and kidney yang deficiency compared to that in the groups characterized by liver and kidney yin deficiency, kidney yang deficiency, and blood stasis and qi stagnation. (P=0.020, P＜0.001, P=0.040). Additionally, compared with the groups characterized by liver and kidney yin deficiency, kidney yang deficiency, and blood stasis and qi stagnation, the group with spleen and kidney yang deficiency had the lowest T-score for bone mineral density, and the difference was statistically significant (P=0.002, P＜0.001, P=0.040). The difference in fracture rates among the four groups was statistically significant (χ2=11.23,P=0.010). The fracture rate in the spleen-kidney yang deficiency group was higher than that in the liver-kidney yin deficiency group (P=0.001). There was no significant difference in PHF and PMOF between groups without substituting bone mineral density T value (H=4.853，P=0.183；H=4.691，P=0.196). Calculating PHF in each group with bone mineral density, spleen and kidney yang deficiency group had a significantly higher PHF compared to the groups with liver-kidney yin deficiency and kidney yang deficiency, with a statistically significant difference (P=0.017, P＜0.001). Similarly, the PMOF was significantly higher in the spleen and kidney yang deficiency group compared to the groups with liver and kidney yin deficiency and kidney yang deficiency, with a statistically significant difference (P=0.025, P=0.001). Conclusion Patients with spleen and kidney yang deficiency have a higher risk of fracture. Using FRAX, a modern medical fracture risk assessment tool, combining with traditional Chinese medicine differentiation, it is expected that OP patients can understand their fracture risk earlier and better prevent fractures. |