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| “亢害承制”理论探讨多器官沟通与骨质疏松症的相关性研究 |
| Exploration of the correlation between multi-organ communication and osteoporosis based on the theory of restraining excessive to acquire harmony |
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| DOI：10.3969/j.issn.1006-7108.2023.09.024 |
| 中文关键词: 骨质疏松症 骨形成 骨破坏 亢害承制 肠道微生态 代谢紊乱 |
| 英文关键词:osteoporosis bone formation bone damage control of hyperactivity intestinal microecology disorder of metabolism |
| 基金项目:甘肃省卫生健康行业科研计划项目（GSWSKY2020-42，GSWSKY2019-89） |
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| 中文摘要: |
| 骨质疏松症是较为常见的增龄性骨重塑障碍性疾病，具备高患病率、高致残率特征，现已成为重要的社会健康问题。中医学将其病机关键概括为机体内稳态失衡、五行生克制化削弱（正常承制关系缺失）及脏腑结构功能紊乱，进一步衍生出扶正防“害”、驱邪治“亢”的干预理念。此外，在疾病进展过程中单一因素致病或单个脏器受邪少见，很大程度上都存在复杂病理网络关系并不断凸显出多器官沟通的连锁效应。基于此，本文以中医学经典理论为基点，全方位、多角度剖析骨质疏松症发病进程中的病理生理机制，以期能不断丰富中医药对抗疾病的科学内涵，并为更深层次临床应用及基础研发提供理论依据。 |
| 英文摘要: |
| Osteoporosis is a common age-related bone remodeling disorder with a high prevalence and disability rate. It has become an important social health problem. It has been summarized in traditional Chinese medicine (TCM) that its key pathogenesis is the imbalance of homeostasis of the body, the weakening of restraint of the five elements (the lack of normal relationship), and the structure and function disorder of the viscera, which further leads to the intervention concept of supporting the right to prevent damage and exorcising evil to cure excess. In addition, in the process of disease progression, it is rare for a single factor to cause the disease or a single organ to be affected by the disease. Complex pathological network relationships exist to a large extent, constantly highlighting the chain effect of multi-organ communication. Based on this, this paper, based on the classical theories of TCM, analyzes the pathophysiological mechanism in the pathogenesis of osteoporosis in a multi-faceted and multi-angle manner, with a view to continuously enrich the scientific connotation of TCM in fighting diseases and to provide theoretical basis for further clinical application and basic research and development. |
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