| Objective To analyze the specificity and sensitivity of quantitative CT (QCT) in the diagnosis of rheumatoid arthritis (RA) complicated with osteoporosis (OP), as well as the influencing factors of bone loss in RA patients assessed by QCT, and to explore the value of QCT in the diagnosis and disease assessment of RA patients complicated with OP. Methods A total of 112 patients with confirmed rheumatoid arthritis were selected as research objects, including QCT group (56 cases) and dual-energy X-ray group (56 cases). Bone mineral density was measured by QCT and DXA respectively in the two groups. General information was collected, including age, sex, body mass index, disease duration (month), previous illness, and medication. Meanwhile, RA-related clinical manifestations, auxiliary examination and bone density examination results were collected. The receiver operating characteristic curve (ROC curve) was used to analyze the specificity and sensitivity of QCT for the diagnosis of OP, and multiple linear regression was used to analyze the correlation between bone loss in QCT group and the clinical manifestations and auxiliary examination of RA.Results 1. After comparison, there was no significant difference in general data between the two groups (P>0.05); The detection rate of osteoporosis in patients with rheumatoid arthritis was 44.6% by DXA and 51.9% by QCT. ROC curve analysis showed that the sensitivity and specificity of QCT for the diagnosis of RA combined with OP were 0.739 and 0.618.3. Bone loss in QCT group was not significantly correlated with clinical manifestations and disease activity indexes in RA patients (P>0.05), but was correlated with RA specific antibody anti-perinuclear factor antibody (APF). Conclusion The detection rate of RA combined OP by QCT is higher than that of DXA, and it has good sensitivity and specificity, which may be used as an important means for the diagnosis of RA combined with OP. |