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| 胸椎QCT诊断骨质疏松BMD阈值的临床研究 |
| The clinical study on diagnostic BMD thresholds of thoracic vertebral for osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2023.10.008 |
| 中文关键词: CT 胸椎 骨质疏松 定量CT 骨密度 |
| 英文关键词:computed tomography thoracic spine osteoporosis quantitative computed tomography bone mineral density |
| 基金项目:河北省财政厅基金项目（LS201804） |
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| 中文摘要: |
| 目的 分析下部胸椎与腰椎骨密度的相关性并确定诊断骨质疏松及骨量减少的胸椎骨密度阈值。方法 回顾性分析因临床需要进行腹部CT扫描的患者276名。测量T10~L3各椎体的BMD，使用Pearson 相关分析各椎体间的BMD及胸椎（T10~12）与腰椎（L1~L3）平均BMD的相关性，应用线性回归方程计算诊断骨质疏松及骨量减少的胸椎平均BMD阈值。结果 T10至L3椎体BMD逐渐减低，BMD范围(120.49±35.96) mg/cm3~(95.62±35.95) mg/cm3, T10~L3各椎体之间BMD均呈明显正相关（r=0.894~0.967，P＜0.05），T10~12平均BMD与L1~3平均BMD相关系数为0.957。胸椎诊断骨质疏松及骨量减少的平均BMD阈值分别是96.59 mg/cm3及134.75 mg/cm3。结论 胸椎与腰椎BMD呈明显相关性，胸椎BMD测量可以作为诊断骨质疏松及骨量减少的方法。 |
| 英文摘要: |
| Objective To analyze the correlation between thoracic and lumbar bone mineral density and to identify specific diagnostic thresholds of osteoporosis and osteopenia for the thoracic spine. Methods Retrospective analysis of 276 patients who received abdomen non-contrast-enhanced CT scan for otherindication. BMD of each vertebra spanning T10–L3 was measured, the correlation between BMD of each vertebral body, mean T10-T12 BMD and mean L1-L3 BMD were analyzed using Pearson analysis. The cut-off values of thoracic spine (T10-12) averaged BMD for osteoporosis and osteopenia were calculated using linear regression. Results The BMD of vertebral body from T10 to L3 gradually decreased, with the highest BMD in the T10(120.49 ± 35.96 mg/cm3) and lowest at L3 (95.62 ± 35.95 mg/cm3). Significant correlations in BMD among all measured thoracic and lumbar levels were observed（r=0.894-0.967, P＜0.05）, and a Pearson’s correlation coefficient between mean T10-T12 BMD and mean L1-L3 BMD was 0.957. Respective cut-off values of mean T10-T12 BMD for osteoporosis and osteopenia was 96.59 mg/cm3 and 134.75 mg/cm3. Conclusion There is a high correlation between mean L1-L3 BMD and mean T10-T12 BMD, BMD measurement of thoracic spine can be used as a method for diagnosis of osteoporosis and osteopenia. |
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