原发性胆汁性胆管炎患者低骨量、骨质疏松危险因素的研究
Study of Risk Factors for Low Bone Mass and Osteoporosis in Patients with Primary Biliary Cholangitis
  
DOI:10.3969/j.issn.1006-7108.2023.10.009
中文关键词:  原发性胆汁性胆管炎  低骨量  骨质疏松  肌少症
英文关键词:primary biliary cholangitis  low bone mass  osteoporosis  sarcopenia
基金项目:国家自然科学基金项目(81660102);云南省科技厅科技计划项目(2018FE001[-051])
作者单位
张静怡1 张宸瑞2 唐映梅2* 1.昆明市第一人民医院消化内科云南 昆明 650032 2.昆明医科大学第二附属医院消化内科云南 昆明 650032 
摘要点击次数: 502
全文下载次数: 0
中文摘要:
      目的 探讨原发性胆汁性胆管炎(primary biliary cholangitis,PBC)患者发生低骨量、骨质疏松的危险因素。方法 采用病例对照的研究方法,回顾性收集2018年11月至2020年6月在昆明医科大学第二附属医院完善了骨密度检查的PBC患者128例,根据骨密度检查结果分为3组,骨量正常组28例,低骨量组58例,骨质疏松组42例,分析PBC患者发生低骨量、骨质疏松的危险因素。结果 在PBC骨量正常、低骨量、骨质疏松3组患者中,年龄、PBC病史、熊去氧胆酸(ursodeoxycholic acid,UDCA)治疗疗程、UDCA治疗应答情况、长期使用利尿剂、肝硬化、腹水、肌少症、高脂血症,以及胆汁酸、DB 、IgA、IL-6水平不同,差异有统计学意义(P<0.05)。其中,高龄、合并腹水、肌少症、高脂血症是PBC患者发生低骨量、骨质疏松的独立危险因素,差异有统计学意义(P<0.05)。 结论 PBC患者低骨量、骨质疏松发生率较高,高龄、腹水、肌少症、高脂血症是PBC患者发生低骨量、骨质疏松的独立危险因素。
英文摘要:
      Objective To investigate the risk factors for the development of low bone mass and osteoporosis in patients with primary biliary cholangitis. Methods A case-control study method was conducted to retrospectively collect 128 patients with primary biliary cholangitis who had perfected bone density examination at the Second Affiliated Hospital of Kunming Medical University from November 2018 to June 2020, and they were divided into three groups according to the bone density examination results, 28 cases in the group with normal bone mass, 58 cases in the group with low bone mass, and 42 cases in the group with osteoporosis, analyzed the risk facrors for the development of low bone mass and osteoporosis in patients with PBC. Results The results showed that among the three groups of patients with normal bone mass, low bone mass, and osteoporosis in PBC, there were statistically significant differences in age, PBC medical history, Ursodeoxycholic acid (UDCA) treatment course, UDCA treatment response, long-term use of diuretics, liver cirrhosis, ascites, sarcopenia, hyperlipidemia, as well as bile acid, DB, IgA, and IL-6 levels (P<0.05). Among them, advanced age, concurrent ascites, sarcopenia, and hyperlipidemia are independent risk factors for low bone mass and osteoporosis in PBC patients, with statistically significant differences (P<0.05). Conclusion PBC patients have a higher incidence of low bone mass and osteoporosis, and elderly age, ascites, sarcopenia, and hyperlipidemia are independent risk factors for low bone mass and osteoporosis in PBC patients.
查看全文  查看/发表评论  下载PDF阅读器
关闭
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=1946763CE42DED5D9314871AAD867B6A651C1090C2F1DA79B522AB0E323D4EC365A516A6E6242D3B52FB9F192D8CD7465BB6590373D3EBECBD72A55CBA27E1411F82850670C92C5C9E70B2A1C1D93A3A6E9E750DC1FB019C1E2486DA5C678A17D84BDFE4A8B1AD01&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=527A01A248DACB72&jid=CA678592D11E309E8E3FB3B2BFE9BE1A&yid=BA1E75DF0B7E0EB2&aid=&vid=&iid=F3090AE9B60B7ED1&sid=B84F40D8DE35D7C0&eid=F5101255A8B0FC04&fileno=20231009&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="527A01A248DACB72"; var my_jid="CA678592D11E309E8E3FB3B2BFE9BE1A"; var my_yid="BA1E75DF0B7E0EB2"; var my_aid="";