| Objective To investigate the risk factors for the development of low bone mass and osteoporosis in patients with primary biliary cholangitis. Methods A case-control study method was conducted to retrospectively collect 128 patients with primary biliary cholangitis who had perfected bone density examination at the Second Affiliated Hospital of Kunming Medical University from November 2018 to June 2020, and they were divided into three groups according to the bone density examination results, 28 cases in the group with normal bone mass, 58 cases in the group with low bone mass, and 42 cases in the group with osteoporosis, analyzed the risk facrors for the development of low bone mass and osteoporosis in patients with PBC. Results The results showed that among the three groups of patients with normal bone mass, low bone mass, and osteoporosis in PBC, there were statistically significant differences in age, PBC medical history, Ursodeoxycholic acid (UDCA) treatment course, UDCA treatment response, long-term use of diuretics, liver cirrhosis, ascites, sarcopenia, hyperlipidemia, as well as bile acid, DB, IgA, and IL-6 levels (P<0.05). Among them, advanced age, concurrent ascites, sarcopenia, and hyperlipidemia are independent risk factors for low bone mass and osteoporosis in PBC patients, with statistically significant differences (P<0.05). Conclusion PBC patients have a higher incidence of low bone mass and osteoporosis, and elderly age, ascites, sarcopenia, and hyperlipidemia are independent risk factors for low bone mass and osteoporosis in PBC patients. |