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| HMGB1介导TLR4/NF⁃κB信号通路干预骨关节炎研究进展 |
| Research progress in the intervention of osteoarthritis by HMGB1 through TLR4/NF-κB signaling pathway |
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| DOI：10.3969/j.issn.1006-7108.2023.10.021 |
| 中文关键词: 骨关节炎 HMGB1/TLR4/NF-κB信号通路 研究进展 |
| 英文关键词:osteoarthritis HMGB1/TLR4/NF-κB signaling pathway research progress |
| 基金项目:兰州市科技发展指导性项目（2020-ZD-65）；甘肃省青年科技基金（20JR10RA345）；甘肃省卫生健康行业科研项目（GSWSKY-2021-009）；兰州市城关区科技局(2020JSCX0065)；甘肃中医药大学附属医院创新基金(gzfy-2020-24)；甘肃省拔尖领军人才项目 |
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| 中文摘要: |
| 骨关节炎(osteoarthritis, OA)作为临床常见老年退行性疾病，目前尚无有效治疗手段。研究发现OA是一种慢性低度炎性疾病。损伤相关分子模式HMGB1（high mobility group box-1）在OA病理过程中发挥中心分子作用。HMGB1与固有免疫模式识别受体TLR4(toll-like receptor 4, TLR4)结合后激活NF-κB信号通路导致OA软骨退变和滑膜炎等免疫炎症反应。通过综述HMGB1介导TLR4/NF-κB信号通路在OA发病机制中的作用，为靶向阻断HMGB1治疗OA提供理论依据和参考。 |
| 英文摘要: |
| Osteoarthritis (OA) is a common clinical degenerative disease, but there is no effective treatment at present. Studies have found that OA is a chronic low-grade inflammatory disease. Damage-related molecular pattern HMGB1 (high mobility group box-1) plays a central molecular role in the pathological process of OA. HMGB1 binds to Toll-like receptor (4TLR4), the innate immune pattern recognition receptor, and activates NF-κB signaling pathway, leading to OA cartilage degeneration and synovitis. This article reviews the role of HMGB1 mediated TLR4/NF-κB signaling pathway in the pathogenesis of OA, so as to provide theoretical basis and reference for the targeted blockade of HMGB1 in the treatment of OA. |
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