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| miR-146a介导TLR4/NF-κB信号通路延缓骨关节炎的作用及机制 |
| The effect and mechanism of miR-146a mediating TLR4/NF-κB signaling pathway in osteoarthritis |
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| DOI：10.3969/j.issn.1006-7108.2023.10.022 |
| 中文关键词: 骨关节炎 miR-146a TLR4/NF-κB信号通路 研究进展 |
| 英文关键词:osteoarthritis miR-146a TLR4/NF-κB signaling pathway research progress |
| 基金项目:甘肃省卫生健康行业科研项目（GSWSKY-2021-009）；兰州市城关区科技计划项目(2020-2-2-7)；甘肃中医药大学附属医院院内创新基金(gzfy-2020-24)；甘肃省科技计划资助（20JR5RA129）；兰州市科技发展指导性计划项目(2022-20-91)；甘肃省青年科技基金计划(20JR10RA345) |
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| 中文摘要: |
| 骨关节炎（osteoarthritis, OA）作为慢性低度炎症性疾病，对它的研究一直是重点和难点，因此如何延缓OA的进展成为最主要的问题。miR-146a作为维持软骨稳态的关键调节因子，其表达的变化对软骨退变和炎症具有调节作用。Toll样受体4(toll-like receptor 4, TLR4)/核因子-κB(nuclear Factor-κB, NF-κB)信号通路通过调节免疫炎症反应，维持软骨代谢稳态。虽然miR-146a介导TLR4/NF-κB信号通路延缓OA已有研究，但是具体作用机制仍然不完善。本研究通过miR-146a介导TLR4/NF-κB信号通路对炎症及软骨细退变方面的综述，为OA的治疗提供理论依据和潜在分子靶标。 |
| 英文摘要: |
| Osteoarthritis (OA) is a chronic low-grade inflammatory disease. It has always been the focus and difficulty. How to delay the progress of OA has become the most important problem. As a key regulator to maintain cartilage homeostasis, miR-146a has a regulatory effect on cartilage degeneration and inflammation. Toll-like receptor 4 (TLR4) / Nuclear Factor-κB (NF-κB) signaling pathway maintains the metabolic homeostasis of cartilage by regulating immune and inflammatory responses. Although it has been studied that miR-146a mediates TLR4/NF-κB signaling pathway to delay OA, the specific mechanism is still not perfectly understood. This study reviews the effects of miR-146a on inflammatory factors, chondrocyte apoptosis, and cartilage extracellular matrix degradation through TLR4/NF-κB signaling pathway, so as to provide theoretical basis and potential molecular targets for the treatment of OA. |
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