|
| “肾气热则骨枯髓减”探讨儿童糖皮质激素性骨质疏松的发病机制 |
| Investigation of the pathogenesis of glucocorticoid-induced osteoporosis in children based on the theory of marrow loss and bone exhaustion caused by warm kidney qi |
| |
| DOI：10.3969/j.issn.1006-7108.2023.10.023 |
| 中文关键词: 糖皮质激素性骨质疏松 儿童 骨痿 中医药 病机 |
| 英文关键词:glucocorticoid-induced osteoporosis children atrophic debility of bones traditional Chinese medicine pathogenesis |
| 基金项目:中华民族医药学会科研项目（20212Z1183-400617）；河南省中医药科学研究专项课题（2019ZY1010，2021ZY2045)；河南省科技厅-河南省科技研发计划联合基金项目-优势学科培育类（222301420078）；河南省自然科学基金面上项目（222300420488）；2022年度河南省健康中青年学科带头人培养项目[豫卫人（2022）26号] |
| 作者 | 单位 | | 马涵琳1,3 张霞1,2,3* 张帅1,3 韩姗姗1,2,3 任献青1,2,3 丁樱1,2,3 | 1.河南中医药大学儿科医学院，河南 郑州 450000
2.河南中医药大学第一附属医院，河南 郑州 450000
3.河南中医药大学，河南 郑州 450000 |
|
| 摘要点击次数: 419 |
| 全文下载次数: 0 |
| 中文摘要: |
| 糖皮质激素性骨质疏松（glucocorticoid- induced osteoporosis，GIOP）是儿童常见的继发性骨质疏松症。因其影响儿童骨骼的正常发育，导致生长发育障碍，降低患儿生活质量，逐渐在世界范围内受到广泛关注。GIOP归属于中医“骨枯”“骨痿”范畴，其产生与“肾气热”密切相关。肾为水脏，水不胜火，则热灼精枯，骨失濡养发而为病。糖皮质激素属阳燥烈之品，为GIOP发病的源头，过用可出现热盛阴虚的证候，与“肾气热则骨枯髓减”所述病机相吻合。本文基于此理论，结合现代医学研究探讨GIOP的中医发病机制，以期为临床辨证治疗提供思路。 |
| 英文摘要: |
| Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis in children.?Because it affects the development of children's bones and leads to growth development disorders, and reduces the quality of life in children, it has gradually attracted wide attention worldwide.?GIOP is classified to the category of bone loss and bone impotence in traditional Chinese medicine. Its occurrence is closely related?to warm kidney qi.?Kidney is the bank of water. Water is conquered by fire. When heat causes marrow exhaustion, the bone is suffered from non-nourishment. Glucocorticoid is the source of GIOP. It belongs to the hot and acrid in traditional Chinese medicine. Overdose?of glucocorticoids may cause consumption of kidney?essence?due to?intense heat, which is consistent with the theory of marrow loss and bone exhaustion caused by warm kidney qi. Based on this theory, this paper explores the pathogenesis of GIOP in traditional Chinese medicine combined with modern medical research, in order to provide ideas for clinical dialectical treatment. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |