ApoE与骨质疏松症相关性的研究进展
Research progress in the association between ApoE and osteoporosis
  
DOI:10.3969/j.issn.1006-7108.2023.10.026
中文关键词:  ApoE  骨质疏松  炎症因子  氧化应激
英文关键词:ApoE  osteoporosis  inflammatory factor  oxidative stress
基金项目:中国博士后科学基金(2022M722249);国家自然科学基金青年科学基金(82001020,82001062);四川大学专职博士后研发基金项目(2022SCU12029)
作者单位
赵付琳1 罗祥1,2 魏强1 张德茂1,2,3 白明茹1,3* 1. 四川大学华西口腔医院口腔疾病国家重点实验室四川 成都 610041 2. 四川大学华西基础医学与法医学学院生物医学工程研究所四川 成都 610041 3. 四川大学华西口腔医院四川 成都 610041 
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中文摘要:
      骨质疏松症(osteoporosis,OP)作为一种比较常见的骨代谢疾病,与高血脂症间存在着一定的关联,临床上同时患有这两种疾病的现象比较常见。当骨吸收增加而骨形成减少时,骨代谢失衡,就会发生OP。载脂蛋白E(ApoE)是血浆中主要的载脂蛋白之一,ApoE功能异常是引起高血脂症的关键。近年来依托ApoE基因敲除鼠模型,在ApoE调节血脂机制及高脂血症与OP的发生过程相关性的研究有了诸多新发现,拓宽了固有认知。本文主要汇总了ApoE近5年与骨相关的研究,分析其影响OP的发生过程的机制,从宏观的血脂和细胞层面到微观的氧化应激和炎症层面,总结了ApoE对骨代谢的重要调节作用,以期为后续研究、新药物筛选及临床应用提供参考依据。
英文摘要:
      As a common bone metabolism disease, osteoporosis has a certain correlation with hyperlipidemia. It is common for patients to suffer from these two diseases at the same time. When bone resorption increases and bone formation reduced, the dynamic balance of bone metabolism is broken, and osteoporosis occurs. Apolipoprotein E (ApoE) is one of the main apoproteins in the plasma. The abnormal function of ApoE is the key to cause hyperlipidemia. In recent years, relying on the ApoE gene knockout mouse model, many new discoveries have been made in the mechanism of ApoE regulating blood lipid and the correlation between the occurrence process of hyperlipidemia and osteoporosis, which has broadened the inherent cognition. This paper mainly summarizes the ApoE and bone related research, analyzes the influence of the occurrence of osteoporosis process mechanism from the macro blood lipid and cell level to the micro oxidative stress and inflammation, summarizes the importance of ApoE in regulating bone metabolism, in order to provide reference for subsequent research, new drug screening, and clinical application.
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