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| NEDD4泛素连接酶家族在骨质疏松症中的研究 |
| The research of NEDD4 ubiquitin ligase family in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2023.10.027 |
| 中文关键词: 泛素化 NEDD4泛素连接酶家族 骨质疏松症 |
| 英文关键词:ubiquitination NEDD4 ubiquitin ligase family osteoporosis |
| 基金项目:国家自然科学基金-4-羟脯氨酸降解信号通路关键基因HOGA-1突变在遗传性多发性骨软骨瘤病发生中的致病机制研究(81572636) |
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| 中文摘要: |
| 骨质疏松症的重要发病原因是骨重塑过程的紊乱，而介导泛素化的NEDD4泛素连接酶家族在这一过程中扮演着关键的角色。其中泛素连接酶Smurf1、Wwp1能够抑制成骨细胞分化，Smurf2则能够抑制促破骨细胞分化因子RANKL的分泌，而Wwp2却是一种成骨的正向促进因子。近年来，有关NEDD4泛素连接酶家族的研究为骨质疏松症的发病机制和治疗提供了许多新的方向。本篇综述总结了NEDD4泛素连接酶家族在骨重塑过程中的调控作用。 |
| 英文摘要: |
| The disruption of bone remodeling process is critical in the pathophysiology of osteoporosis. NEDD4 ubiquitin ligase family, which mediates ubiquitination, plays a key role in this process. In the NEDD4 ubiquitin ligase family, the ubiquitin ligases Smurf1 and Wwp1 prevent osteoblasts from differentiation, Smurf2 stops osteoclasts from secreting the osteoclast differentiation factor RANKL, and Wwp2 promotes osteogenesis. The study of NEDD4 ubiquitin ligase family provides many new directions for the pathogenesis and treatment of osteoporosis. This review summarizes the regulatory role of NEDD4 ubiquitin ligases in the process of bone remodeling. |
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