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| 膳食模式通过微生物群-肠道-骨轴影响骨质疏松 |
| Dietary patterns affect osteoporosis through the microbiota-gut-bone axis |
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| DOI：10.3969/j.issn.1006-7108.2023.11.017 |
| 中文关键词: 骨质疏松 膳食模式 肠道微生物群 肠道-骨骼轴 导向膳食干预 |
| 英文关键词:osteoporosis dietary pattern gut microbiota gut-bone axis oriented dietary intervention |
| 基金项目:中央引导地方科技发展专项项目-甘肃地区多发病防治能力提升创新平台；国家自然基金地区项目（82160911，81860864）；甘肃省青年科技基金计划（20JR5RA129）；中央高校基本科研业务费项目（31920210041）；敦煌医学与转化教育部重点实验室开放课题（DHYX19-05）；甘肃省第二人民医院院内重点项目（YNZD2021-2） |
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| 中文摘要: |
| 目前，一种新治疗理念——微生物群落导向食物干预膳食策略的提出，为骨质疏松（osteoporosis，OP）的防治提供了新途径新选择。基于该理念的提出及当前通过宏基因组学对骨质疏松研究的深入，本文讨论了国际使用最广泛的3种膳食模式（西方膳食模式、地中海膳食模式、素食膳食模式）、肠道微生物群（gastrointestinal microflora，GM）、骨质疏松之间的潜在联系，总结了这3种膳食模式影响下GM的变化情况，及GM变化后调节肠道-骨骼轴对OP的影响途径。发现，地中海膳食模式和素食膳食模式下，GM发生有利变化，OP风险降低；而西方膳食模式下GM发生不利变化，OP发病率上升且严重程度增加。本综述明确了以肠道微生物群为纽带的膳食模式与骨质疏松的证据相关性，展望了实现骨质疏松患者肠道微生物群落导向膳食干预的可能。 |
| 英文摘要: |
| At present, a new therapeutic concept-microbial community-oriented dietary intervention strategy provides a new approach for the prevention and treatment of Osteoporosis (OP) .Based on this concept and the current research on osteoporosis through metagenomics, this article discusses the potential links between the three most widely used dietary patterns internationally (Western, Mediterranean and vegetarian) , the Gastrointestinal microflora (GM) and osteoporosis, the changes of GM under the three dietary patterns were summarized, and the ways of regulating gut-bone axis to OP after the changes of GM were discussed.The results showed that in Mediterranean diet and vegetarian diet, the risk of OP decreased, while in western diet, the risk of OP increased and the incidence of OP increased. This review clarifies the evidence of the relationship between intestinal microbiome - linked dietary patterns and osteoporosis and looks forward to the possibility of implementing intestinal microbiome - oriented dietary interventions in osteoporosis patients. |
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