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| 肠道微生物代谢产物丁酸对骨代谢机制的研究进展 |
| Research progress on the mechanism of butyric acid, a metabolic product of gut microbiota, on bone metabolism |
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| DOI：10.3969/j.issn.1006-7108.2023.11.026 |
| 中文关键词: 丁酸 骨代谢 内分泌系统 免疫系统 |
| 英文关键词:butyric acid bone metabolism endocrine system immune system |
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| 中文摘要: |
| 丁酸是肠道微生物代谢产物短链脂肪酸的一种，已被证明是成骨细胞和破骨细胞代谢的调节剂。本文通过以下几个方面阐述丁酸对骨代谢的调节：①调节钙磷水平促进骨形成；②维持肠上皮屏障的功能；③调节免疫系统和内分泌系统等。研究证明，补充丁酸和促进丁酸生成的益生菌能够促进骨形成，抑制骨吸收。因此丁酸可能成为骨质疏松等与骨代谢相关疾病的防治新靶点。 |
| 英文摘要: |
| Butyric acid, a short-chain fatty acid metabolized by intestinal microorganisms, has been shown to be a regulator of osteoblast and osteoclast metabolism. This paper expounds the regulation of butyric acid on bone metabolism from the following aspects: ① Regulate calcium and phosphorus levels to promote bone formation. ②Maintaining the function of intestinal epithelial barrier. ③Regulate the immune system and endocrine system. Research has shown that supplementing butyric acid and promoting probiotics can promote bone formation and inhibit bone resorption. Therefore, butyric acid may be a new target for the prevention and treatment of bone metabolism-related diseases such as osteoporosis. |
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