| Senescence of bone marrow mesenchymal stem cells (BM-MSCs) results in the decreased plasticity and regeneration potential, impaired migration and homing ability, and the senescence-associated secretory phenotype (SASP), and leads to compromised tissue repair and immune protect function, as well as induced chronic inflammation, causing age-related bone tissue degeneration. Moreover, senescence reduces the effectiveness while increases the risk of BM-MSCs application in cell therapy. Therefore, research in BM-MSCs senescence is of great importance for the prevention and treatment of aging-associated bone tissue degenerative diseases, and the improvement of BM-MSCs clinical application. In this paper, the latest research progress in BM-MSCs senescence is reviewed. The new strategies and ideas to inhibit BM-MSCs senescence are also suggested. |