| Objective To explore the effect of different motor subtypes on osteoporosis in patients with Parkinson's disease. Methods A total of 101 patients with Parkinson's disease who were admitted to the Department of Neurology, the Affiliated Huai’an First People’s Hospital of Nanjing Medical University from July 2021 to February 2023 were selected and scored on the Unified Parkinson's Rating Scale (UPDRS) Ⅲ and the Parkinson's Disease Quality of Life Questionnaire (PDQ-39). Patients with Parkinson's disease were classified into tremor-dominant type and akinetic-rigid dominant type based on UPDRSⅢ scores. The differences of osteoporosis incidence in patients with akinetic-rigid dominant (ARD) were compared to those with tremor-dominant type. The potential risk factors were explored. Results (1) The incidence of osteoporosis, PDQ39, HAMA, and HAMD-24 in ARD type were higher than those in TD type, and the difference was statistically significant (P<0.05). (2) The female proportion, ARD proportion, UPDRSⅢ score, PDQ39, HAMA, and HAMD-24 in osteoporosis group were higher than those in non-osteoporosis group, and the differences were statistically significant (P<0.05). (3) Correlation analysis showed that the incidence of osteoporosis in PD patients was positively correlated with female (r=0.34, P<0.001), ARD type (r=0.31, P=0.002), and UPDRSⅢ score (r=0.43, P<0.001). (4) Binary Logistic regression analysis showed that the female (OR=3.06, 95%CI: 1.18-7.94, P=0.022), ARD type (OR=4.53, 95%CI: 1.70-12.09, P=0.003), UPDRSⅢ score (OR=1.11, 95%CI: 1.04-1.19, P=0.001) were independent risk factors for osteoporosis in PD. Conclusion The ARD type of Parkinson's disease is closely related to the occurrence of osteoporosis, which seriously affects the quality of life of patients with Parkinson's disease. |