| Objective To summarize the research progress of active components and mechanism of Sambucus williamsii Hance in treating osteoporosis, and provide reference for its further research, development and utilization. Methods Using CNKI, wanfang data, VIP, Web of Science and PubMed databases, the domestic and foreign literatures published from 1992 to 2022 about Sambucus williamsii Hance in treating osteoporosis were searched, read and summarized. Results Many chemical components in Sambucus williamsii have anti-osteoporosis effects, mainly lignans. It was found that the active components of Sambucus williamsii can regulate the formation and differentiation of osteoblasts and osteoclasts, regulate ERK MAPK signal transduction pathway, participate in amino acid and lipid metabolism and inhibit osteoporosis. Conclusion Sambucus williamsii Hance has great potential in the treatment of osteoporosis, which is worthy of further study. |