内分泌治疗绝经后乳腺癌继发骨质疏松症的研究进展
The research progress of endocrine therapy for osteoporosis secondary to postmenopausal breast cancer
  
DOI:10.3969/j.issn.1006-7108.2024.02.014
中文关键词:  内分泌治疗  绝经后乳腺癌  骨质疏松症  研究进展
英文关键词:endocrine therapy  postmenopausal breast cancer  osteoporosis  research progress
基金项目:国家自然科学基金资助项目(82060908);内蒙古自治区自然科学基金项目(2019MS08149);内蒙古自治区卫生健康委员会项目(202202140);内蒙古自治区教育厅项目(JGSZ2023042)
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蒋召磊 刘春慧* 马建超 沈卓睿 李彦宾 白涵睿 内蒙古医科大学中医学院内蒙古 呼和浩特 010110 
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中文摘要:
      内分泌治疗绝经后乳腺癌继发骨质疏松症是亟待解决的全球公共卫生问题之一。绝经后乳腺癌与骨质疏松症密切相关。对于绝经后乳腺癌患者,西医多用内分泌治疗药物中的芳香化酶抑制剂,虽然能有效控制雌激素水平,提高生存率,但是会增加骨质疏松症、骨折发生的风险。因此,很有必要进行相关骨检测。对于骨质疏松症,西医药物治疗多用双膦酸盐类,短期疗效较为满意,但存在时间限制,不能长期应用。西医非药物治疗以调整生活方式为主。中医治疗本病的内治法,多从肝、脾、肾论治,能提高骨密度,减轻骨痛等症状,降低骨折的风险,疗效较为显著,副作用较少。中医外治法采用针灸、穴位埋线、穴位贴敷等疗法。本文从中西医两方面对内分泌治疗绝经后乳腺癌继发骨质疏松症的研究进展进行综述,以期在中西医防治本病方面取得更好的进展,为临床和科研提供更多的依据。
英文摘要:
      Endocrine therapy for osteoporosis secondary to postmenopausal breast cancer is a global public health disease to be solved urgently. Postmenopausal breast cancer is closely associated with osteoporosis.For postmenopausal breast cancer patients, Western medicine often use aromatase inhibitors in endocrine therapy drugs, although it can effectively control the level of estrogen and improve the survival rate, it will increase the risk of osteoporosis and fracture.Therefore, it is very necessary to carry out related bone examination.For this disease, Western medicine is often used in the treatment of bisphosphonates, the short-term effect is more satisfactory, but there is a time limit, can not be used for a long time.Non-drug treatment in Western medicine focuses on adjusting lifestyle.The internal treatment of this disease in traditional Chinese medicine, mainly from the liver, spleen and kidney treatment, can increase bone mineral density, reduce bone pain and other symptoms, reduce the risk of fracture, the curative effect is more significant, less side effects.The external treatment of traditional Chinese medicine adopts acupuncture, acupoint burying, acupoint applying and other therapies.This article reviews the research progress of endocrine treatment of postmenopausal breast cancer secondary osteoporosis from two aspects of traditional Chinese and Western medicine, in order to make better progress in the prevention and treatment of this disease, and provide a better basis for clinical and scientific research.
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