| Intestinal flora and its metabolites have been shown in maintaining the body's normal physiological and pathological process played an important role.Trimethylamine-N-oxide is one of the main metabolites of intestinal flora, the cardiovascular diseases, diseases such as diabetes, high blood pressure and chronic kidney disease (CKD) plays an important role in the development of recent experiments prove trimethylamine-N-oxide and osteoporosis have direct connection, the study found that trimethylamine-N-oxide from oxidative stress, the NF-κB signaling pathways, NLRP3 inflammatory corpuscle, mediated between bone marrow mesenchymal stem cells, etc, to promote osteoporosis, the finding that "Gut-Bone" theory of shaft is the content of the supplement and rich.This article reviews the research progress on the mechanism of trimethylamine-N-oxide mediated osteoporosis, and explores the possibility of trimethylamine-N-oxide as a therapeutic target and biomarker for osteoporosis. |