| Semaphorin 3A (Sema 3A) is a member of the signaling family. It is involved in axon guidance, cardiovascular development, tumor formation, regulation of immune cells, and bone homeostasis. NRP-1 plays a role as its co-receptor. In recent years, research has found that the Sema 3A/NRP-1 pathway promotes bone formation, inhibits bone resorption, and regulates bone metabolism. Specifically, it regulates bone metabolism through the classic Wnt/β-catenin signaling pathway, sGC-cGMP signaling pathway, neuromodulation, RANK-RANKL pathway, inflammatory response regulation, and other pathways. We review the relevant literature both domestically and internationally in recent years, with the aim of providing reference for the prevention and treatment of OP. |