| Objective This study aimed to investigate the health-related quality of life and health utility value of hospitalized osteoporosis patients and to analyze the factors that influence them. Methods The study collected general data of osteoporosis patients hospitalized in Gansu Provincial Hospital, detected bone metabolism indexes, measured bone mineral density of the lumbar spine and hip, assessed fall risk, predicted fractures, evaluated quality of life, and calculated health utility values. The Mann-Whitney test and the Kluscal-Wallis test were used for univariate analysis. The Tobit regression model was used to analyze the factors affecting the quality of life of participants. Results A total of 241 hospitalized osteoporosis patients were enrolled as study subjects. Their health utility value was 0.876 (0.728-0.942). Univariate analysis showed that age, education, risk of falls, place of residence, smoking, previous use of anti-osteoporosis drugs, low-invasive fracture history, FRAX score, left hip T-value, and calcium were associated with health utility values in patients with osteoporosis (P<0.05). The results of the Tobit regression model showed that a high literacy rate (primary school: β=0.119, P=0.043; junior high school: β=0.113,P=0.044; high school or college or technical school β=0.171, P=0.002) was a protective factor for quality of life. High risk of fall (intermediate risk β=?0.138, P<0.001; high-risk β=?0.316, P<0.001), low-invasive fracture history (β=?0.190, P<0.001), and FRAX score of high risk (β=?0.088,P=0.027) were risk factors for quality of life. Conclusion The health utility value of hospitalized osteoporosis patients is lower than that of the general population, indicating poor health-related quality of life. Patients with low literacy rate, high risk of fall, fractures, and high risk of FRAX score have poorer quality of life. Improving the quality of life of patients, promoting health, preventing falls, and active intervening are necessary. |