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| 肌少症与睡眠障碍关系研究 |
| Advances in research on the relationship between sarcopenia and sleep disorders |
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| DOI：10.3969/j.issn.1006-7108.2024.03.015 |
| 中文关键词: 肌少症 睡眠障碍 内分泌失调 慢性炎症 体力活动不足 |
| 英文关键词:sarcopenia sleep disorders endocrine disorders chronic inflammation physical inactivity |
| 基金项目:山东省自然科学基金(ZR2018HL041)；青岛大学医疗集团科研专项 |
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| 中文摘要: |
| 肌少症是以?骼肌质量减少、肌力下降为主要表现的以老年人群和慢性疾病患者为主要群体的疾病，其主要的致病因素包括内分泌代谢失调、体力活动不足、慢性炎症等。最近，睡眠障碍对肌少症的影响开始受到关注，较多的研究显示睡眠障碍与肌少症之间存在相关性。睡眠障碍会导致昼夜交替紊乱进而影响胰岛素、性激素等激素分泌，同时会促进促炎性炎症因子的分泌，这些因素都会导致骨骼肌蛋白的合成和分解异常，可能引起肌少症的发生。因此，研究两者之间的关系、针对睡眠障碍开展的治疗可能对于肌少症的防治起到一定效果，是干预肌少症发展的潜在治疗策略。 |
| 英文摘要: |
| Sarcopenia is a disease mainly characterized by a decrease in skeletal muscle mass and muscle strength in the elderly population and chronic disease patients. Its main pathogenic factors include endocrine metabolic disorders, insufficient physical activity, chronic inflammation, etc. Recently, the impact of sleep disorders on sarcopenia has begun to receive attention, more studies have shown a correlation between sleep disorders and sarcopenia. Sleep disorders can lead to circadian disorders and thus affect the secretion of hormones such as insulin and sex hormones, as well as promote the secretion of pro-inflammatory inflammatory factors, all of which can lead to abnormal synthesis and breakdown of skeletal muscle proteins and may cause the development of sarcopenia. Therefore, exploring the relationship between the two and targeting sleep disorders may be effective in the prevention and treatment of sarcopenia and is a potential treatment strategy to intervene in the development of sarcopenia. |
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