| Sarcopenia is a syndrome of loss of skeletal muscle mass and function with age, which increases the risk of falls and fractures. It is one of the main causes of disability and death in the elderly. At present, studies have found that patients with sarcopenia have iron overload. However, it is lack of comprehensive review it. Iron, as the essential element of the body, its metabolism disorder may cause cellular dysfunction and oxidative damage. Exploring the relationship between iron overload and sarcopenia is of positive s1ignificance for clarifying the pathological mechanism of sarcopenia and for providing treatment plans. In this paper, the research of the relation between iron overload and sarcopenia is reviewed. We summarize the potential pathways related to iron overload and sarcopenia, including oxidative damage, mitochondrial damage, and ubiquitin ligase induced muscle atrophy and ferroptosis, in order to provide reference for clarifying the pathological mechanism and clinical practice. |