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| 抗菌肽LL-37在骨质疏松症中的作用机制研究进展 |
| Research progress on mechanism of Antimicrobial peptide LL-37 in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2024.03.025 |
| 中文关键词: 抗菌肽LL-37 骨质疏松症 骨代谢 |
| 英文关键词:cathelicidin LL-37 osteoporosis bone metabolism |
| 基金项目:湖南省卫生健康委科研项目（20200968）；衡阳市科技局科研项目（2019jh010988） |
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| 中文摘要: |
| 抗菌肽（antimicrobial peptides，AMPS）是一种宿主防御肽，既往主要关注其抗细菌及抗病毒作用，进一步研究发现AMPS可在成骨、破骨、免疫、促进血管生成等多个途径调控骨代谢、参与骨质疏松症的发生发展。本文旨在总结AMPS在骨代谢中的调控机制，探讨其对骨质疏松症的影响为AMPS治疗骨质疏松症提供理论依据。 |
| 英文摘要: |
| Antimicrobial peptide (AMPS) is a host defense peptide. Its antibacterial and antiviral effects are paid attention in previous studies. Further studies have shown that cathelicidin LL-37 regulates bone metabolism through multiple pathways and participates in the occurrence and development of osteoporosis, such as osteogenesis, osteoclast, immunity, and promoting angiogenesis. This article reviews the mechanism of LL-37 in bone metabolism and its influence in osteoporosis, aiming to explore the relationship between AMPS and osteoporosis and to provide theoretical basis for the treatment of osteoporosis with AMPS. |
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