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| CircRNA_0001445在老年性骨质疏松症中的表达及临床意义 |
| Expression of CircRNA_0001445 in senile osteoporosis and its clinical significance |
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| DOI：10.3969/j.issn.1006-7108.2024.04.007 |
| 中文关键词: 老年性骨质疏松 CircRNA_0001445 表达 临床意义 |
| 英文关键词:senile osteoporosis circRNA_0001445 expression clinical significance |
| 基金项目:江苏省卫生健康委员会老年健康科研项目（LR2022012）；江苏省卫生健康委员会老年健康科研项目（LD2022008） |
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| 中文摘要: |
| 目的 探究血浆circRNA_0001445在老年性骨质疏松症（senile osteoporosis，SOP）中的表达情况及其临床意义。方法 选取2020年11月至2022年5月于常州市第一人民医院老年科住院的患者为研究对象，应用双能X射线吸收检测法（DXA）测量骨密度（bone mineral density，BMD）根据BMD结果分为SOP组、骨量减少组及骨量正常组，比较各组间临床资料及circRNA_0001445表达量，采用Pearson相关分析circRNA_0001445与骨密度的的相关性；采用二元Logistic回归分析SOP的危险因素；采用受试者工作特征（ROC）曲线分析circRNA_0001445对SOP的诊断价值；采用配对t检验或配对秩和检验比较SOP治疗前后circRNA_0001445表达量变化。结果 共纳入150例患者，每组各50例。SOP组circRNA_0001445表达量（0.58±0.30）明显低于骨量减少组（0.88±0.35）及骨量正常组（1.15±0.62），P＜0.001；Pearson相关分析示circRNA_0001445表达量与腰椎BMD（r=0.427，P＜0.001）、股骨颈BMD（r=0.363，P＜0.001）及髋部BMD（r=0.435，P＜0.001）存在正相关；二元Logistic回归示高TC（OR=2.740,95%CI：1.473-5.099）、低BMI（OR=0.674,95%CI：0.543-0.837）及circRNA_0001445（OR=0.019，95 %CI：0.002~0.144）是SOP发生的危险因素，P＜0.05。ROC曲线分析显示，circRNA_0001445可将SOP组与骨量正常组（AUC=0.810，95 ％CI：0.728~0.892）、骨量减少组（AUC=0.756，95 ％CI：0.662~0.849）及非SOP组（AUC=0.783，95 ％CI：0.706~0.860）区分开来。SOP治疗1年后circRNA_0001445表达量较前升高（1.13±0.61 vs 2.14±0.61），P＜0.001。结论 circRNA_0001445在SOP中低表达，对SOP的诊断及治疗监测具有一定临床价值。 |
| 英文摘要: |
| Objective To investigate the expression of circRNA_0001445 in plasma in senile osteoporosis (SOP) and its clinical significance. Methods Patients hospitalized in the Department of Geriatric, the First People’s Hospital of Changzhou from November 2020 to May 2022 were collected. All subjects were measured bone mineral density(BMD) by dual-energy X-ray absorptiometry(DXA) and divided into SOP group, osteopenia group and normal bone mass group according to BMD level. The clinical data and circRNA_0001445 expression levels were compared in each group. The correlation between circRNA_0001445 and BMD was analyzed by Pearson correlation analysis. The risk factors of SOP were analyzed by binary logistic regression. The diagnostic value of circRNA_0001445 in SOP was analyzed by receiver operating characteristic (ROC) curve. The changes of circRNA_0001445 expression levels before and after treatment was compared by paired-samples t test or paired-samples rank sum test. Results A total of 150 patients were included in this study, each group had 50 samples. The expression of circRNA_0001445 in SOP group (0.58±0.30) was significantly lower than that in osteopenia group (0.88±0.35) and normal bone mass group (1.15±0.62), P<0.001; Pearson correlation analysis showed that circRNA_0001445 expression was positively correlated with lumbar spine BMD(r=0.427, P< 0.001), femoral neck BMD (r=0.363, P <0.001) and hip BMD (r=0.435, P < 0.001).Binary logistic regression showed high TC (OR=2.740,95%CI: 1.473-5.099), low BMI (OR=0.674,95%CI: 0.543-0.837) and circRNA_0001445 (OR=0.019,95%CI:0.002-0.144) were risk factors for SOP, P< 0.05.ROC curve analysis showed that circRNA_0001445 could distinguish SOP patients from normal bone mass patients(AUC=0.810, 95 %CI: 0.728-0.892) , osteopenia patients (AUC=0.756, 95%CI: 0.662-0.849) and non-SOP patients(AUC=0.783, 95%CI:0.706-0.860).After 1 year of SOP treatment, the expression of circRNA_0001445 was higher than before (1.13±0.61 vs 2.14±0.61), P<0.001. Conclusion The circRNA_0001445 showed low expression in SOP, which has certain clinical value for diagnosis and treatment monitoring of SOP. |
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