| Fractures are the most common in skeletal muscle injuries, and some of them may experience delayed or even non union of the bone. However, effective drug treatment for this condition has not yet been found. Various stage of fracture healing is influenced by various factors, among which different signaling pathways and related cytokines play key roles in the healing process. Various studies have shown that the Hedgehog signaling pathway affects stem cell proliferation and differentiation, inflammatory response, bone reconstruction, nerve regeneration, angiogenesis, and other aspects during the healing process, and may be jointly regulated by various hormones and other signaling pathways, indicating that the Hedgehog signaling pathway is closely related to fracture healing. This article provides a comprehensive review from multiple perspectives, exploring the role of the Hedgehog signaling pathway in different stage of the healing process, hoping to provide new targets and treatment methods for the fracture healing treatment. |