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| 脂氧素A4在运动改善骨关节炎中的作用与机制研究 |
| Research on the role and mechanism of lipoxin A4 in relieving osteoarthritis by exercise |
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| DOI：10.3969/j.issn.1006-7108.2024.04.018 |
| 中文关键词: 骨关节炎 运动 脂氧素A4 炎症反应 |
| 英文关键词:osteoarthritis exercise lipoxin A4 inflammation response |
| 基金项目:国家重点研发计划“中国人群精准运动处方研制与运动处方库建设”（2018YFC2000604）；中央高校基本科研业务费专项资金资助项目（2023051） |
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| 中文摘要: |
| 骨关节炎（osteoarthritis, OA）是一种慢性关节疾病，主要表现为软骨退行性改变、滑膜炎症及关节功能衰退。在其病理发展中，炎症反应及炎症因子的过度释放起关键作用。脂氧素A4（lipoxin A4，LXA4），是一种具有显著抗炎特性的脂质调节因子，在OA的发病中展现出内源性抗炎和免疫调节效应。近期研究揭示，作为OA的非药物治疗策略，运动能显著调控LXA4水平及炎症反应。LXA4能抑制NF-κB和p38-MAPK信号通路，缓解OA相关炎症和疼痛。运动能激活12-氧脂合酶（12-LOX）和氧化脂质途径，增强LXA4合成，并进一步通过与滑膜成纤维细胞、巨噬细胞及中性粒细胞的交互作用，降低炎症因子水平。运动的强度和频率也对LXA4水平和OA治疗效果产生影响。中至高强度运动在提升LXA4水平和抑制炎症因子方面表现尤为显著，但高强度运动可能对软骨产生负面效应。目前适宜的运动模式为每次20~30 min，每日2~3次，间隔4 h，此模式在降低软骨分解相关酶及优化软骨组织结构方面展现出卓越效果。 |
| 英文摘要: |
| Osteoarthritis (OA) represents a chronic joint disorder, predominantly exhibiting cartilage degeneration, synovial inflammation, and deterioration of joint function. The pathological progression involves critical roles of inflammatory reactions and an over-release of inflammatory cytokines. lipoxin A4 (LXA4), a lipid mediator with pronounced anti-inflammatory characteristics, exhibits intrinsic anti-inflammatory and immunomodulatory effects in the onset of OA. Recent studies have unveiled that physical activity, serving as a non-drug therapeutic strategy for OA, notably modulates LXA4 levels and inflammatory reactions. LXA4 is capable of suppressing NF-κB and p38-MAPK signaling, mitigating inflammation and pain associated with OA. Physical activity activates 12-lipoxygenase (12-LOX) and lipid oxidation pathways, bolsters LXA4 synthesis, and further, diminish levels of inflammatory cytokines by interaction with synovial fibroblasts, macrophages, and neutrophils. The intensity and frequency of exercise also impart an impact in LXA4 levels and the therapeutic efficacy for OA. Moderate to high-intensity exercise notably excels in elevating LXA4 levels and inhibits inflammatory factors. However, high-intensity exercise may exert negative effects on cartilage. At present, the optimal exercise regimen involves 20-30 minutes per session, 2-3 sessions daily, with a 4-hour interval, exhibiting outstanding results in diminishing enzymes related to cartilage breakdown and optimizing cartilage tissue structure. |
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