| Osteoporosis is a common metabolic bone disease. Its pathogenesis is closely related to the disruption of bone homeostasis. Bone homeostasis relies on the precise dynamic balance between osteoclastic bone resorption and osteoblastic bone formation. Mitochondrial quality control includes mitochondrial biogenesis, mitochondrial dynamics, oxidative stress, and mitophagy. Mitochondrial function is considered to play an important role in maintaining bone homeostasis. Mitochondrial dysfunction, when exacerbated by defective quality control mechanisms, leads to apoptosis or functional abnormalities in osteoblasts and osteoclasts. Mitochondrial biogenesis, dynamics, and mitophagy play a crucial role in clearing damaged mitochondria, renewing the mitochondrial population, and influencing osteoblast differentiation and osteoblastic formation. Furthermore, the balance of bone metabolism critically relies on mitochondrial oxidative stress. Excessive oxidative stress may aggravate the inflammatory state of the medullary cavity environment. Mitochondrial quality control is the cornerstone of restoring mitochondrial disorders, promoting cellular homeostasis through adaptive responses, and protecting mitochondrial structure, morphology, quantity, and function. Therefore, this review comprehensively outlines the effects of mitochondrial quality control on osteoporosis, which contributes to a better understanding of the molecular mechanism of osteoporosis and provides reference for the subsequent development of more natural drugs. |