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| Sirtuin家族调控骨关节炎软骨细胞的作用机制研究进展 |
| Research progress on the mechanism of sirtuin family regulation of chondrocytes in osteoarthritis |
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| DOI：10.3969/j.issn.1006-7108.2024.04.023 |
| 中文关键词: 骨关节炎 软骨细胞 Sirtuin |
| 英文关键词:osteoarthritis chondrocyte sirtuin |
| 基金项目:国家自然科学基金资助项目(82060876)；甘肃省重点研发计划-社会发展领域项目（22YF7FA103） |
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| 中文摘要: |
| 骨关节炎（osteoarthritis，OA）是常见的慢性退行性疾病，以关节软骨的进行性破坏为主要病理特征。研究证实软骨组织中软骨细胞功能障碍是OA进展的关键因素，包括能量代谢、生物钟、自噬和凋亡的异常激活及衰老软骨细胞的增加等生物过程。沉默信息调节因子（sirtuin，SIRT）是依赖于烟酰胺烟嘌呤二核苷酸的去乙酰化酶家族，通过参与并调节软骨细胞功能过程中的蛋白质去乙酰化，从而延缓OA进展。依据文献报道，本文将围绕SIRT家族成员对OA软骨细胞功能的调控作用机制进行概述，旨在对SIRT家族在OA软骨细胞的作用机制有进一步认识和为今后靶向治疗OA提供思路。 |
| 英文摘要: |
| Osteoarthritis (OA) is a common chronic degenerative disease with progressive
destruction of articular cartilage as its main pathological feature. Studies have confirmed
that the dysfunction of chondrocytes in cartilage tissue is a key factor in the progression of OA, including the abnormal activation of energy metabolism, biological clock,autophagyand apoptosis, and the increase of senescent chondrocytes. Silencing message regulators
(sirtuin) are a family of niacinamide and niacinopine dinucleotide-dependent deacetylases
that delay the progression of OA by participating in and regulating protein deacetylation
during chondrocyte function. According to literature reports, this paper will focus on the
regulatory mechanism of SIRT family members on the function of OA chondrocytes,
aiming to further understand the mechanism of SIRT family in OA chondrocytes and
provide ideas for future targeted treatment of OA. |
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