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| Chemerin/ChemR23信号通路在骨代谢调控中的研究进展 |
| Research advances on Chemerin/ChemR23 signaling pathway in bone metabolism regulation |
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| DOI：10.3969/j.issn.1006-7108.2024.04.027 |
| 中文关键词: Chemerin ChemR23 骨代谢 骨质疏松 |
| 英文关键词:Chemerin ChemR23 bone metabolism osteoporosis |
| 基金项目:贵州省高层次创新型人才项目[黔科合平台人才（2020）6015-2]；贵州省科技计划项目［黔科合支撑（2021）一般076］ |
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| 中文摘要: |
| Chemerin是一种新发现的脂肪因子，可与高亲和力受体ChemR23结合，广泛参与多种生理过程的调节。研究证实，Chemerin/ChemR23信号传导通路与骨代谢调控高度相关。主要通过调控MAPK、PI3K/Akt、Wnt/β-catenin、NF-κB等关键信号通路及调节睾酮合成，影响骨代谢。本文综述Chemerin/ChemR23信号通路在骨代谢调控中的研究进展以及与骨质疏松的相关研究，以提高临床对Chemerin/ChemR23信号通路与骨代谢疾病相关性的认识。 |
| 英文摘要: |
| Chemerin is a newly discovered adipokine that binds to its high-affinity receptor ChemR23 and participates extensively in the regulation of various physiological processes. Studies have confirmed that the Chemerin/ChemR23 signaling pathway is highly relevant to bone metabolism regulation. It mainly regulates bone metabolism by modulating key signaling pathways including MAPK, PI3K/Akt, Wnt/β-catenin, NF-kB, and regulating testosterone synthesis. This article reviews the research progress on the Chemerin/ChemR23 signaling pathway in bone metabolism regulation and its correlation with osteoporosis, to improve the clinical understanding of the relevance between Chemerin/ChemR23 signaling pathway and bone metabolic diseases. |
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