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| 中老年2型糖尿病合并肌少症与NLR等炎症标志物的相关性 |
| Correlation between type 2 diabetes mellitus complicated with sarcopenia and inflammatory markers such as NLR in the middle-aged and elderly people |
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| DOI：10.3969/j.issn.1006-7108.2024.05.010 |
| 中文关键词: 2型糖尿病 肌少症 中性粒细胞/淋巴细胞比值 炎性因子 |
| 英文关键词:type 2 diabetes mellitus sarcopenia neutrophil-to-lymphocyte rate inflammatory factor |
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| 中文摘要: |
| 目的 探讨中老年2型糖尿病（T2DM）合并肌少症与中性粒细胞计数/淋巴细胞计数（NLR）等炎症标志物的关系。方法 选择2022年11月至2023年5月在华北理工大学附属医院内分泌科及全科医学科住院的2型糖尿病患者251例，依据合并肌少症情况将患者分为T2DM组和T2DM合并肌少症组。收集患者基本情况、临床指标等数据，计算NLR等炎症标志物。采用多因素Logistic回归分析肌少症与NLR等炎症标志物的关系。结果 与T2DM组比较,T2DM合并肌少症组年龄、白细胞、尿酸、NLR、MHR水平均升高，HDL-C水平降低，差异有统计学意义（P<0.05）。多因素Logistic回归结果显示, NLR水平升高、增龄是T2DM合并肌少症的独立危险因素，HDL-C水平升高是T2DM合并肌少症的独立保护因素（P<0.05）。ROC曲线分析显示，研究对象NLR预测T2DM合并肌少症的AUC为0.737 (95% CI：0.646~0.828）。结论 在中老年T2DM患者中，NLR水平升高是肌少症的独立危险因素，NLR对预测T2DM合并肌少症有一定的价值。 |
| 英文摘要: |
| Objective To investigate the relationship between type 2 diabetes mellitus (T2DM) combined with sarcopenia and inflammatory markers such as neutrophil count/lymphocyte count (NLR) in the middle-aged and elderly. Methods Two hundred and fifty-one patients with type 2 diabetes mellitus hospitalized in the Department of Endocrinology and Department of Family Medicine of the Affiliated Hospital of North China University of Science and Technology were selected from November 2022 to May 2023. The patients were divided into T2DM group and T2DM combined with myasthenia gravis group. Data on patients' basic conditions and clinical indicators were collected. Inflammatory markers such as NLR were calculated. The relationship between sarcopenia and inflammatory markers such as NLR was analyzed using multifactorial logistic regression. Results Compared to those in the T2DM group, age, leukocyte, uric acid, NLR, and MHR levels were elevated, HDL-C levels decreased, and the difference was statistically significant (P<0.05). The results of multifactorial logistic regression showed that elevated NLR levels and increasing age were independent risk factors for T2DM combined with sarcopenia. The elevated HDL-C level was an independent protective factor for T2DM combined with sarcopenia (P<0.05). ROC curve analysis showed that the AUC of NLR for predicting T2DM combined with sarcopenia in the study population was 0.737 (95% CI: 0.646-0.828). Conclusion In the middle-aged and elderly patients with type 2 diabetes mellitus, elevated NLR level is an independent risk factor for sarcopenia. NLR is valuable in predicting T2DM combined with sarcopenia. |
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