人工虎骨粉治疗绝经后骨质疏松的临床疗效
Clinical efficacy of the artificial tiger bone powder in the treatment of postmenopausal osteoporosis
  
DOI:10.3969/j.issn.1006-7108.2024.05.012
中文关键词:  骨质疏松症  人工虎骨粉  骨密度  跌倒风险  躯体能力
英文关键词:osteoporosis  artificial tiger bone powder  BMD  fall risk  physical performance
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作者单位
顾宏菲1 赵玲1 李旭云1 孔令成1 毛一凡1 李茜茜2 史晓林2 李威3* 1.浙江中医药大学附属富阳中医骨伤医院浙江 杭州 311400 2.浙江中医药大学附属第二医院浙江 杭州 310005 3.浙江中医药大学浙江 杭州 310053 
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中文摘要:
      目的 观察人工虎骨粉对绝经后骨质疏松症患者骨密度、躯体能力及骨折跌倒风险的影响。方法 将浙江中医药大学附属富阳中医骨伤医院门诊收治的160例绝经后骨质疏松症患者分为对照组及试验组,每组80例。对照组予以阿法骨化醇软胶囊+钙尔奇D3片+阿仑膦酸钠片,试验组在此基础上增加人工虎骨粉胶囊进行治疗,比较两组患者骨密度、跌倒效能量表评分、简易躯体能力测试、脆性骨折及跌倒发生变化率等并进行统计分析。结果 ①研究过程中,试验组和对照组分别有2例和4例退出试验,最后共收集154例患者数据;②骨密度:治疗12个月后试验组与对照组骨密度均较治疗前提高,差异具有统计学意义(P<0.05),且试验组骨密度提升更优,两组比较差异具有统计学意义(P<0.05);③简易躯体能力测试:试验组在治疗6个月及12个月后躯体、下肢和移动能力比治疗前改善明显,差异具有统计学意义(P<0.05),治疗12个月后试验组躯体能力测试改善优于对照组,差异具有统计学意义(P<0.05);④跌倒效能量表:试验组在治疗6个月及12个月后跌倒效能评分均较治疗前提高,差异具有统计学意义(P<0.05),并且与对照组比较,跌倒效能量评分更优,差异具有统计学意义(P<0.05);⑤跌倒及骨折发生率:试验组跌倒24次,跌倒发生率30.77 %;对照组跌倒35次,跌倒发生率46.05 %。试验组骨折4次,骨折发生率5.13 %;对照组骨折6次,骨折发生率7.89 %。结论 人工虎骨粉可有效改善患者骨密度、躯体活动能力,降低跌倒风险,降低骨折发生率,比单纯三联用药效果更佳。
英文摘要:
      Objective To observe the effect of artificial tiger bone powder on bone mineral density, physical capacity, fall risk, and fracture risk in patients with postmenopausal osteoporosis. Methods One hundred and sixty postmenopausal patients with osteoporosis were divided into control group and experimental group by random number table method, with 80 cases in each group. Patients in the control group received Alfacalciferol capsule+calcic D3 tablets+alendronate sodium tablets. On the basis of this, patients in the experimental group received artificial tiger bone powder capsule for treatment. The data of BMD, MFES, SPPB, fragile fractures, and fall incidence of patients were compared for statistical analysis. Results ①One hundred and fifty-four patients were eventually gathered from the trial, after two patients from the experimental group and four patients from the control group withdrew during the study; ②BMD: following a 12-month course of treatment, baseline BMD showed improvement both in the experimental and in the control group, and the difference was statistically significant (P<0.05). The BMD improvement in the experimental group was greater than that in the control group, and the difference was also statistically significant (P<0.05); ③SPPB: The experimental group showed a statistically significant difference between baseline and 6 and 12 months of treatment (P<0.05). The control group also showed a statistically significant difference after 12 months of treatment (P<0.05). The experimental group also performed better on the SPPB after 12 months of treatment than the control group, with the difference being statistically significant (P<0.05); ④MFES: the comparison between the two groups showed that the MFES of the experimental group was better than that of the control group after 6 and 12 months of treatment, with a statistically significant difference (P<0.05). The difference between the experimental group and the control group after 12 months of treatment and before treatment was also statistically significant (P<0.05);⑤ Incidence of falls and fractures: The falls in the experimental group were 24 times, and the incidence of falls was 30.77%. The falls in the control group were 35 times, and the incidence of fall was 46.05%. The fractures in the experimental group were 4 times, and the fracture rate was 5.13%. The fractures in the control group were 6 times, and the fracture rate was 7.89%. Conclusion The artificial tiger bone powder effectively improves bone mineral density, physical activity, reduces the risk of fall, and reduces the incidence of fractures. The effect is better than that of simple triple drug.
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