ATP诱导细胞死亡与骨质疏松调控
ATP induced cell death and regulation of osteoporosis
  
DOI:10.3969/j.issn.1006-7108.2024.05.015
中文关键词:  ATP诱导细胞死亡  骨质疏松症  发病机制  治疗策略
英文关键词:ATP-induced cell death  osteoporosis  pathogenesis  treatment strategies
基金项目:国家自然科学基金(81960877);甘肃省高等学校创新基金(2021A-076;2023A-088);甘肃省科技计划(创新基地和人才计划)项目(21JR7RA561);敦煌医学与转化教育部重点实验室开放基金项目(DHYX20-16;DHYX21-01;DHYX2021-07;DHYX22-05);甘肃省中医药研究中心专项开放课题(zyzx-2020-zx10);甘肃省自然基金(21JR1RA267;22JR5RA582);甘肃省教育科技创新项目(2022A-067);甘肃省科技计划项目重点研发计划国际科技合作类(23YFWA0005)
作者单位
潘静1 赵瑞1 杨钰婷2 齐雅茜1 刘志1 王薇2 张忠文3 张浩令4* 宋志靖1,5* 1.甘肃中医药大学中医临床学院甘肃 兰州 730000 2.甘肃中医药大学针灸推拿学院甘肃 兰州 730000 3.甘肃中医药大学公共卫生学院甘肃 兰州 730000 4.马来西亚理科大学高级医学和牙科研究所马来西亚 槟城 13200 5.敦煌医学与转化教育部重点实验室甘肃 兰州 730000 
摘要点击次数: 32
全文下载次数: 0
中文摘要:
      骨质疏松症作为一种广泛存在的骨骼系统疾病,其发病机制至今尚未完全阐明。研究表明,ATP诱导的细胞死亡与成骨细胞、破骨细胞和骨髓间充质干细胞之间存在着密切的关系,其通过多个途径影响骨吸收、骨形成和骨代谢涉及骨组织的动态平衡和骨质疏松症的发病机制,进而参与骨质疏松症的病理过程。本文综述了ATP诱导细胞死亡的分子机制,深入探讨了ATP在骨质疏松症中的作用机制,旨在为骨质疏松症提供新的研究靶点和诊疗思路。
英文摘要:
      Osteoporosis, as a widespread skeletal system disease, its pathogenesis has not been fully elucidated. Studies have shown that there is a close relationship between ATP-induced cell death and osteoblasts, osteoclasts and bone marrow mesenchymal stem cells. ATP-induced cell death affects bone resorption, bone formation, and bone metabolism through multiple ways, involving the homeostasis of bone tissue and the pathogenesis of osteoporosis, and then participates in the pathological process of osteoporosis. In this paper, the molecular mechanism of ATP-induced cell death is reviewed, and the action mechanism of ATP in osteoporosis is deeply discussed, aiming to provide new research targets and diagnosis and treatment ideas for osteoporosis.
查看全文  查看/发表评论  下载PDF阅读器
关闭
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=B9B0F8B3E1444E2FAEB01D3907D09A71672A24BCC1C7D5A428FA9E18918FB510D11C0EB0CE8DC60CA27546290A5FF7A1D4330D12DB8C79DA&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=527A01A248DACB72&jid=CA678592D11E309E8E3FB3B2BFE9BE1A&yid=B80136CCD8DCBAA1&aid=&vid=&iid=94C357A881DFC066&sid=7D2B339649A57040&eid=E008F9AD6D4B96EF&fileno=202405015&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="527A01A248DACB72"; var my_jid="CA678592D11E309E8E3FB3B2BFE9BE1A"; var my_yid="B80136CCD8DCBAA1"; var my_aid="";