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| 淫羊藿苷修复骨缺损及其作用机制研究 |
| Research progress of icariin in repairing bone defect and its mechanism of action |
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| DOI：10.3969/j.issn.1006-7108.2024.05.018 |
| 中文关键词: 淫羊藿苷 骨缺损 成骨细胞 骨形成 作用机制 |
| 英文关键词:icariin bone defect osteoblast bone formation action mechanism |
| 基金项目:甘肃省自然科学基金项目（22JR11RA013）；联勤保障部队第九四〇医院实验室培育项目（2021yxky081）；联勤保障部队第九四〇医院青年培育项目（2021yxky053）；甘肃省青年科技基金计划（22JR5RA020）；兰州市科技计划项目（2003-8-1） |
| 作者 | 单位 | | 杨世超1,2 宋慕格1,2 李幸1 王立强1,2 安梓栋1,2 柏鑫1,2 魏振龙1,3 高玉海1,3 陈克明1,2,3* | 1. 中国人民解放军联勤保障部队第九四〇医院基础医学实验室, 甘肃 兰州 730050
2. 甘肃中医药大学中医临床学院, 甘肃 兰州 730000
3. 甘肃省干细胞与基因药物重点实验室, 甘肃 兰州 730050 |
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| 中文摘要: |
| 骨缺损治疗一直是困扰骨科的一大难题，由于骨的再生能力有限，大面积的骨缺损常无法自行愈合。淫羊藿苷（icariin，ICA）在骨形成方面的效果明显，淫羊藿含有的ICA是一种黄酮类化合物和活性化合物，具有促进骨形成和抑制骨吸收的双重活性，并且可以通过多种生物材料进行局部递送，促进骨缺损修复，展现出良好的的骨诱导潜力。研究发现，ICA主要通过促进骨形成、软骨形成、血管生成、抑制骨吸收和抗炎作用修复骨缺损。本文就ICA修复骨缺损及其作用机制加以概述，以期为后续研究提供一定参考。 |
| 英文摘要: |
| The treatment of bone defects has always been a major problem in orthopedics. Due to the limited regenerative capacity of bone, large-scale bone defects often cannot be healed by themselves. Icariin (ICA) has an obvious effect on bone formation. ICA contained in Icariin is a flavonoid compound and an active compound, which has dual activities of promoting bone formation and inhibiting bone absorption. Icariin can also be delivered locally through a variety of biological materials to promote bone defect repair, showing a good bone induction potential. It has been found that ICA mainly repairs bone defects by promoting bone formation, cartilage formation, angiogenesis, and by inhibiting bone resorption and anti-inflammatory effects. In this paper, ICA repair of bone defect and its mechanism of action are summarized in order to provide some reference for the follow-up research. |
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