淫羊藿苷修复骨缺损及其作用机制研究
Research progress of icariin in repairing bone defect and its mechanism of action
  
DOI:10.3969/j.issn.1006-7108.2024.05.018
中文关键词:  淫羊藿苷  骨缺损  成骨细胞  骨形成  作用机制
英文关键词:icariin  bone defect  osteoblast  bone formation  action mechanism
基金项目:甘肃省自然科学基金项目(22JR11RA013);联勤保障部队第九四〇医院实验室培育项目(2021yxky081);联勤保障部队第九四〇医院青年培育项目(2021yxky053);甘肃省青年科技基金计划(22JR5RA020);兰州市科技计划项目(2003-8-1)
作者单位
杨世超1,2 宋慕格1,2 李幸1 王立强1,2 安梓栋1,2 柏鑫1,2 魏振龙1,3 高玉海1,3 陈克明1,2,3* 1. 中国人民解放军联勤保障部队第九四〇医院基础医学实验室, 甘肃 兰州 730050 2. 甘肃中医药大学中医临床学院, 甘肃 兰州 730000 3. 甘肃省干细胞与基因药物重点实验室, 甘肃 兰州 730050 
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中文摘要:
      骨缺损治疗一直是困扰骨科的一大难题,由于骨的再生能力有限,大面积的骨缺损常无法自行愈合。淫羊藿苷(icariin,ICA)在骨形成方面的效果明显,淫羊藿含有的ICA是一种黄酮类化合物和活性化合物,具有促进骨形成和抑制骨吸收的双重活性,并且可以通过多种生物材料进行局部递送,促进骨缺损修复,展现出良好的的骨诱导潜力。研究发现,ICA主要通过促进骨形成、软骨形成、血管生成、抑制骨吸收和抗炎作用修复骨缺损。本文就ICA修复骨缺损及其作用机制加以概述,以期为后续研究提供一定参考。
英文摘要:
      The treatment of bone defects has always been a major problem in orthopedics. Due to the limited regenerative capacity of bone, large-scale bone defects often cannot be healed by themselves. Icariin (ICA) has an obvious effect on bone formation. ICA contained in Icariin is a flavonoid compound and an active compound, which has dual activities of promoting bone formation and inhibiting bone absorption. Icariin can also be delivered locally through a variety of biological materials to promote bone defect repair, showing a good bone induction potential. It has been found that ICA mainly repairs bone defects by promoting bone formation, cartilage formation, angiogenesis, and by inhibiting bone resorption and anti-inflammatory effects. In this paper, ICA repair of bone defect and its mechanism of action are summarized in order to provide some reference for the follow-up research.
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