中医药通过NF-κB信号通路治疗骨关节炎的研究进展
The research progress of traditional Chinese medicine regulate NF-κB signaling pathway in the treatment of osteoarthritis
  
DOI:10.3969/j.issn.1006-7108.2024.05.019
中文关键词:  NF-κB  骨关节炎  氧化应激  炎症反应  发病机制
英文关键词:NF-κB  osteoarthritis  oxidative stress  inflammatory response  pathogenesis
基金项目:国家自然科学基金(81774343);全国名老中医专家传承工作室(2021-2024);2023年黑龙江中医药管理局中医药科研项目(ZHY2023-045);中央支持地方高校改革发展资金人才培养项目(2019年项目)
作者单位
刘江燕1 张晓峰1* 徐西林2 李朝霞1 段洪超3* 1黑龙江中医药大学黑龙江 哈尔滨150040 2黑龙江中医药大学附属第三医院黑龙江 哈尔滨150016 3黑龙江中医药大学附属第二医院黑龙江 哈尔滨150001 
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中文摘要:
      随着全球人口老龄化的进展,骨关节炎的发病率也逐年上升,必将成为一大社会公共卫生问题。骨关节炎发病机制复杂,中药因其多成分、多途径、多靶点的特点在治疗骨关节炎方面具有巨大潜力。大量研究表明中医药可通过调节NF-κB信号通路抑制炎症反应、氧化应激、基质降解、细胞凋亡等治疗骨关节炎。本文综述了中医药通过NF-κB通路治疗骨关节炎的研究进展,以期为未来的基础和临床研究提供参考。
英文摘要:
      With the progress of global aging, the incidence rate of osteoarthritis is also increasing year by year, which will become a main social and public health problem. The pathogenesis of osteoarthritis is complex. Traditional Chinese medicine has great potential in the treatment of osteoarthritis because of its multi-component, multi-channel and multi target characteristics. Numerous studies have shown that traditional Chinese medicine can regulate NF- κ B signaling pathway inhibits inflammatory response, oxidative stress, matrix degradation, cell apoptosis and so on to treat osteoarthritis. This article reviews the research progress of traditional Chinese medicine regulate NF-κB signaling pathway in the treatment of osteoarthritis, which expecting to provide reference for future basic and clinical research.
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