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| 中医药通过NF-κB信号通路治疗骨关节炎的研究进展 |
| The research progress of traditional Chinese medicine regulate NF-κB signaling pathway in the treatment of osteoarthritis |
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| DOI：10.3969/j.issn.1006-7108.2024.05.019 |
| 中文关键词: NF-κB 骨关节炎 氧化应激 炎症反应 发病机制 |
| 英文关键词:NF-κB osteoarthritis oxidative stress inflammatory response pathogenesis |
| 基金项目:国家自然科学基金（81774343）;全国名老中医专家传承工作室（2021-2024）；2023年黑龙江中医药管理局中医药科研项目（ZHY2023-045）；中央支持地方高校改革发展资金人才培养项目（2019年项目） |
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| 中文摘要: |
| 随着全球人口老龄化的进展，骨关节炎的发病率也逐年上升，必将成为一大社会公共卫生问题。骨关节炎发病机制复杂，中药因其多成分、多途径、多靶点的特点在治疗骨关节炎方面具有巨大潜力。大量研究表明中医药可通过调节NF-κB信号通路抑制炎症反应、氧化应激、基质降解、细胞凋亡等治疗骨关节炎。本文综述了中医药通过NF-κB通路治疗骨关节炎的研究进展，以期为未来的基础和临床研究提供参考。 |
| 英文摘要: |
| With the progress of global aging, the incidence rate of osteoarthritis is also increasing year by year, which will become a main social and public health problem. The pathogenesis of osteoarthritis is complex. Traditional Chinese medicine has great potential in the treatment of osteoarthritis because of its multi-component, multi-channel and multi target characteristics. Numerous studies have shown that traditional Chinese medicine can regulate NF- κ B signaling pathway inhibits inflammatory response, oxidative stress, matrix degradation, cell apoptosis and so on to treat osteoarthritis. This article reviews the research progress of traditional Chinese medicine regulate NF-κB signaling pathway in the treatment of osteoarthritis, which expecting to provide reference for future basic and clinical research. |
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