骨免疫学视角下绝经后骨质疏松症防治新靶点:MΦ-BMSCs串扰
A novel target for postmenopausal osteoporosis prevention and treatment from the perspective of osteoimmunology: MΦ-BMSCs crosstalk
  
DOI:10.3969/j.issn.1006-7108.2024.05.020
中文关键词:  绝经后骨质疏松症  骨免疫学  巨噬细胞  间质干细胞  串扰
英文关键词:postmenopausal osteoporosis  osteoimmunology  macrophage  mesenchymal stem cells (MSCs)  crosstalk
基金项目:2022年青年岐黄学者培养项目[国中医药人教函(2022)256号];中国中医科学院优秀青年科技人才培养专项达标课题(ZZ13-YQ-039);江苏省科技计划专项(基础研究计划自然科学基金,BK20220468)
作者单位
李琰1 刘宁1 齐保玉1 王旭1 孙传睿1 章轶立2* 魏戌1* 1.中国中医科学院望京医院北京 100102 2.南京中医药大学中西医结合学院江苏 南京210023 
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中文摘要:
      绝经后骨质疏松症(postmenopausal osteoporosis , PMOP)是以骨量下降、骨结构破坏、易发生骨折为特征的代谢性骨病。PMOP已严重威胁女性健康,制约社会经济发展。近年来雌激素缺乏引起PMOP相关机制研究取得进展,但仍未得到充分阐明。骨免疫学研究显示PMOP病理过程伴随着慢性炎症和免疫系统的参与。巨噬细胞(macrophage, MΦ)是重要的免疫细胞,被报道在骨稳态和再生中发挥作用。巨噬细胞的耗竭能加重OVX小鼠的骨丢失,减少骨髓间充质干细胞(bone mesenchymal stem cells, BMSCs)数量,降低BMSCs成骨分化能力。巨噬细胞的缺失对骨形成的影响似乎超过了其对破骨细胞活性的影响,MΦ与BMSCs之间的串扰可能在这一环节发挥着重要作用。本文基于骨免疫学理论对MΦ-BMSCs串扰和PMOP的相关性进行综述,旨在为PMOP的防治研究提供新思路。
英文摘要:
      Postmenopausal osteoporosis (PMOP) is a common bone metabolic disease characterized by decreased bone mass, destruction of bone structure, and an increased risk of fracture. PMOP has become an unfavorable factor that threatens women's health and economic development. Studies on the mechanism associated with estrogen deficiency-induced PMOP have progressed in recent years, but remain insufficiently elucidated. Osteoimmunologic studies have shown that the pathological process of PMOP is accompanied by inflammation and involvement of the immune system. Macrophages, an important component of immune system cells, have been reported to play a role in bone homeostasis and regeneration. Macrophage depletion exacerbates bone loss in OVX mice, and significantly reduces the number of BMSCs and their osteogenic differentiation capacity. The effect of macrophage deletion on bone formation appears to outweigh its effect on osteoclast activity, and crosstalk between MΦ and BMSCs may play an important role in this process. This paper reviews the correlation between the crosstalk of MΦ-BMSCs and postmenopausal osteoporosis based on the theory of osteoimmunology, aiming to provide new ideas for research on the prevention and treatment of PMOP.
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